Analysis of choriocapillaris perfusion and choroidal layer changes in patients with chronic central serous chorioretinopathy randomised to micropulse laser or photodynamic therapy.

The British Journal of Ophthalmology
Mary HoMarten Brelen

Abstract

The purpose of this study was to investigate the signal changes in choriocapillaris flow deficits and choroidal thickness changes using swept-source optical coherence tomography angiography (OCTA) following different treatments. A double-blind, randomised controlled trial. Patients with unilateral chronic central serous chorioretinopathy (CSC) were randomised to receive subthreshold micropulse laser therapy (MLT) or half-dose photodynamic therapy (PDT). Choroidal thickness and choriocapillaris flow deficit signals were investigated. Eighteen patients were randomised into the MLT group and 15 patients into the PDT group. Areas with flow deficit signals were identified in all baseline OCTA images of the choriocapillaris, with mean areas of 0.420 and 0.465 mm2 in the MLT and PDT groups, respectively. These flow deficit signal areas were significantly reduced at 6 months (p=0.011) in the MLT group and at 3 months (p=0.008) in the PDT group. Patients from the PDT group were shown to have smaller flow deficit areas than patients from the MLT group at all time points after treatment (p=0.001, analyses of variance). The mean choroidal volume of the fovea showed a significant reduction at 1 month (p=0.003), 3 months (p=0.199) and 6 mont...Continue Reading

References

Nov 1, 1984·The British Journal of Ophthalmology·C M GilbertS L Fine
May 18, 2010·Ophthalmology·Ichiro MarukoRichard F Spaide
Feb 27, 2013·Investigative Ophthalmology & Visual Science·Alfred K YuDavid G Telander
Jun 6, 2013·Investigative Ophthalmology & Visual Science·Lihong YangWenbin Wei
Jun 12, 2013·Retina·David J WarrowK Bailey Freund
Jan 25, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Zeynep AlkinAhmet Demirok
Jun 1, 2015·Progress in Retinal and Eye Research·Alejandra DaruichFrancine Behar-Cohen
Aug 6, 2015·Investigative Ophthalmology & Visual Science·Michel M TeussinkThomas Theelen
Dec 4, 2015·Journal of Ophthalmology·Eliana CostanzoEric H Souied
Apr 12, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Nikolaus FeuchtLukas Reznicek
Sep 9, 2016·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Ari ShinojimaMitsuko Yuzawa
Feb 9, 2017·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Yishuang XuChangzheng Chen
Apr 7, 2017·Investigative Ophthalmology & Visual Science·Massimo NicolòCarlo Enrico Traverso
Nov 22, 2017·International Journal of Molecular Sciences·Marco NassisiChiara M Eandi
Nov 7, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Cheolmin YunJaeryung Oh
Jan 9, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sibel DemirelEmin Özmert

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Citations

Nov 6, 2020·Pharmaceuticals·Maurizio Battaglia ParodiFrancesco Bandello
Aug 6, 2021·Journal of Ophthalmology·Mary HoFrank Lai
Aug 14, 2021·Clinical & Experimental Ophthalmology·Danny Siu-Chun NgTimothy Y Y Lai
Jan 20, 2022·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Evita Evangelia ChristouMaria Stefaniotou

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