Abstract
The aim of the present study was to determine the proportion of gamma/delta T-lymphocytes and CD16/CD56 (CD3- and CD3+) cells in the peripheral blood of children and adolescents with Graves' disease (GD; n = 27; mean age, 15.5 +/- 5.1 y) and nontoxic nodular goiter (NTNG; n = 25; mean age, 15.2 +/- 5.7 y), in comparison with sex- and age-matched healthy control subjects (n = 25; mean age, 15.9 +/- 2.4 y). In addition, in patients with GD, we investigated the effect of methimazole therapy on the proportion of these cells. We also looked for associations among the parameters investigated. The percentages of gamma/delta TCR+CD3+ lymphocytes and CD3+, CD16/56+CD3+, and natural killer (NK) cells were analyzed by the three-color flow cytometry using a Coulter EPICS XL cytometer. In patients with untreated GD, we observed a significant decrease in gamma/delta T (CD3+) (p < 0.002), CD16/56(CD3+) (p < 0.001), and NK (p < 0.001) cells in comparison with the healthy control subjects. After 2-6 mo of methimazole therapy, the percentages of gamma/delta TCR+CD3+ and CD16/56(CD3+) cells in peripheral blood of hyperthyroid patients returned to the normal values, whereas the percentages of NK cells normalized after 18-24 mo of therapy. These ab...Continue Reading
References
Feb 1, 1992·Clinical and Experimental Immunology·C OliveS W Serjeantson
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K W WucherpfennigD A Hafler
Dec 1, 1988·Nature·M BonnevilleS Tonegawa
Apr 1, 1988·The Journal of Clinical Endocrinology and Metabolism·H TezukaN Ishikawa
Feb 1, 1987·The Journal of Clinical Investigation·M PapicM A Fletcher
Dec 1, 1994·Immunity·P S LinsleyR Peach
Jan 1, 1995·Clinical and Experimental Immunology·A BuchtR Kiessling
Feb 1, 1995·European Journal of Endocrinology·M MarazuelaA Durántez
Nov 1, 1993·Clinical and Experimental Immunology·N IshikawaS Nagataki
Dec 1, 1993·Journal of Endocrinological Investigation·P SantamariaJ J Barbosa
Dec 1, 1993·Clinical and Experimental Immunology·R S McIntoshA P Weetman
May 1, 1993·Clinical and Experimental Immunology·I C Roura-MirR Pujol-Borrell
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·G AustH J Heberling
Dec 1, 1995·Immunity·M A Gavin, M J Bevan
Nov 1, 1996·The Journal of Endocrinology·J J CorralesM T Mories
Jan 1, 1997·Immunology Today·G De Libero
May 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F J LasoA Orfao
Mar 11, 1998·Current Opinion in Immunology·A Hayday, L Geng
Sep 17, 1998·Endocrine Research·S SasiánJ A Girón
Oct 3, 1998·European Journal of Endocrinology·J RojanoJ A Girón
Dec 16, 1998·Thyroid : Official Journal of the American Thyroid Association·B E WenzelJ R Wall
Mar 31, 1999·European Journal of Endocrinology·M Marazuela
Jan 3, 2001·The Journal of Clinical Investigation·P M Vanhoutte
Mar 10, 2001·The Journal of Clinical Investigation·K TakahashiT Yamamura
Citations
Jul 17, 2013·Arthritis Research & Therapy·Leslie A FogelAnthony R French
Oct 5, 2014·International Immunopharmacology·Yupan ZhangYanfang Jiang
Oct 13, 2005·Hormone Research·Artur BossowskiMirosława Urban
Jan 5, 2006·Autoimmunity·A BossowskiJ Dadan
Apr 27, 2018·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Mohamed A SolimanNaglaa Fathy Barseem