Analysis of circulating T gamma/delta lymphocytes and CD16/56 cell populations in children and adolescents with Graves' disease

Pediatric Research
Artur BossowskiAnna Stasiak-Barmuta

Abstract

The aim of the present study was to determine the proportion of gamma/delta T-lymphocytes and CD16/CD56 (CD3- and CD3+) cells in the peripheral blood of children and adolescents with Graves' disease (GD; n = 27; mean age, 15.5 +/- 5.1 y) and nontoxic nodular goiter (NTNG; n = 25; mean age, 15.2 +/- 5.7 y), in comparison with sex- and age-matched healthy control subjects (n = 25; mean age, 15.9 +/- 2.4 y). In addition, in patients with GD, we investigated the effect of methimazole therapy on the proportion of these cells. We also looked for associations among the parameters investigated. The percentages of gamma/delta TCR+CD3+ lymphocytes and CD3+, CD16/56+CD3+, and natural killer (NK) cells were analyzed by the three-color flow cytometry using a Coulter EPICS XL cytometer. In patients with untreated GD, we observed a significant decrease in gamma/delta T (CD3+) (p < 0.002), CD16/56(CD3+) (p < 0.001), and NK (p < 0.001) cells in comparison with the healthy control subjects. After 2-6 mo of methimazole therapy, the percentages of gamma/delta TCR+CD3+ and CD16/56(CD3+) cells in peripheral blood of hyperthyroid patients returned to the normal values, whereas the percentages of NK cells normalized after 18-24 mo of therapy. These ab...Continue Reading

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K W WucherpfennigD A Hafler
Feb 1, 1987·The Journal of Clinical Investigation·M PapicM A Fletcher
Feb 1, 1995·European Journal of Endocrinology·M MarazuelaA Durántez
Dec 1, 1993·Journal of Endocrinological Investigation·P SantamariaJ J Barbosa
Dec 1, 1993·Clinical and Experimental Immunology·R S McIntoshA P Weetman
May 1, 1993·Clinical and Experimental Immunology·I C Roura-MirR Pujol-Borrell
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·G AustH J Heberling
Jan 1, 1997·Immunology Today·G De Libero
May 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F J LasoA Orfao
Mar 11, 1998·Current Opinion in Immunology·A Hayday, L Geng
Dec 16, 1998·Thyroid : Official Journal of the American Thyroid Association·B E WenzelJ R Wall
Mar 31, 1999·European Journal of Endocrinology·M Marazuela
Jan 3, 2001·The Journal of Clinical Investigation·P M Vanhoutte
Mar 10, 2001·The Journal of Clinical Investigation·K TakahashiT Yamamura

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