Analysis of clinical efficacy, side effects, and laboratory changes among patients with acne vulgaris receiving single versus twice daily dose of oral isotretinoin

Dermatologic Therapy
Hesham M Ahmad

Abstract

Acne vulgaris is a debilitating disorder and requires proper treatment. This work evaluates the clinical efficacy, side effects, and laboratory changes of serum lipids and liver function during oral isotretinoin therapy for acne vulgaris, comparing single versus twice daily dose. Fifty-eight patients with acne vulgaris were included and randomized into group I (26 patients), who received once daily dose, and group II (32 patients), who received twice daily dose of oral isotretinoin. Global acne scoring system was used to evaluate acne severity and post-treatment improvement. Both regimens resulted in highly significant clinical improvement of acne with no significant difference. However, side effects were significantly more common among patients of group I. Both regimens caused mild rise of serum cholesterol, alanine transaminase (ALT), and aspartate aminotransferase (AST) with more prominent rise of triglycerides especially with twice daily dose. Oral isotretinoin is a very effective treatment for acne vulgaris with no statistically significant difference in clinical efficacy between once and twice daily doses. However, dividing dose to twice per day might cause fewer incidence of side effects without reducing clinical efficac...Continue Reading

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Citations

Dec 15, 2015·Cutaneous and Ocular Toxicology·Levent ÇinarMurat Borlu
Mar 5, 2016·Cutaneous and Ocular Toxicology·Burcu YesilkayaS Levent Cinar
Mar 8, 2018·International Journal of STD & AIDS·Rami A Ballout, Ismael Maatouk
Nov 27, 2019·Dermatologic Therapy·Gülcan Saylam KurtipekGökhan Güngör
Feb 23, 2020·Dermatologic Therapy·Mrinal GuptaMohamad Goldust
Aug 30, 2020·International Journal of Dermatology·Haady Fallah, Marius Rademaker
Mar 16, 2017·Dermatologic Therapy·Piotr BrzezinskiJanusz Smigielski
Nov 30, 2018·The Cochrane Database of Systematic Reviews·Caroline S CostaRachel Riera
Jul 20, 2020·Dermatologic Therapy·Raul E Ruiz-LozanoJesus Alberto Cardenas-de la Garza
Aug 4, 2020·Expert Review of Clinical Pharmacology·Edileia Bagatin, Caroline Sousa Costa
Jan 4, 2022·International Ophthalmology·Ugur GurlevikErdogan Yasar

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