Analysis of clinical outcome of patients with poorly differentiated thyroid carcinoma.

ISRN Endocrinology
Katsuhiro TanakaJunichi Kurebayashi

Abstract

Background. We retrospectively analyzed whether poor differentiation is the independent prognostic factor for thyroid carcinoma or not. Methods. The subjects were 29 patients with PDTC who were treated between April 1996 and March 2006 to compare with those of well-differentiated papillary carcinoma patients (n = 227). Results. The relapse free (RFS), distant relapse-free survival and cause-specific survival, rates were significantly lower in patients with PDTC (P < .0001, P < .001, and P < .05). After classification into focal (<10%) and diffuse type (over 10%) of PDTC, there were no significant differences in RFS and cause-specific survival due to component type or proportion of poorly differentiated component. On multivariate analysis, poor differentiation (P < .0005, RR = 4.456, 95% CI; 1.953-10.167) and extrathyroidal infiltration (P < .05, RR = 2.898, 95% CI; 1.278-6.572) showed a significant impact on DFS, and poor differentiation (P < .05, RR = 9.343, 1.314-66.453) and age (P < .005, RR = 1.306, 1.103-1.547) significantly impacted cause-specific survival. Conclusion. Poor differentiation was an independent factor for survival. Distant relapse was significantly more common among PDTC patients, and systemic therapy might ...Continue Reading

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Citations

Nov 16, 2013·Annals of Nuclear Medicine·Zekiye HasbekTaner Erselcan
Jul 8, 2017·Endocrinology and Metabolism·Marc Gregory YuCecilia Jimeno
Oct 24, 2019·Case Reports in Endocrinology·Eleonora MolinaroRossella Elisei
Mar 15, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Shivakumar ThiagarajanDevendra Chaukar
May 1, 2021·Journal of Clinical Medicine·Elisa Stellaria GrassiLuca Persani

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