Analysis of cognitive and psychological deficits in systemic lupus erythematosus patients without overt central nervous system disease

Arthritis and Rheumatism
E KozoraB L Kotzin

Abstract

To examine cognitive and psychological functioning in relation to antiribosomal P protein autoantibodies in patients with systemic lupus erythematosus (SLE) who had no previous history of central nervous system disease (non-CNS SLE). Comprehensive neuropsychological and psychological tests were administered to 51 non-CNS SLE patients, 29 rheumatoid arthritis (RA) patients, and 27 healthy controls. Twenty-nine percent of the non-CNS SLE patients, 31% of the RA patients, and 11% of the control subjects were classified as cognitively impaired. Similar reductions in intelligence, attention, and fluency were detected in the non-CNS SLE and RA patients compared with controls. The non-CNS SLE patients showed a distinct deficit in learning compared with the RA and control groups. Forty-two percent of the non-CNS SLE patients demonstrated psychological distress, compared with 7% of the RA patients and 6% of the controls. In the patient groups, neither cognitive dysfunction nor psychological distress was associated with disease activity or prednisone dosage. Elevated serum levels of autoantibodies to ribosomal P protein were not associated with either psychological or cognitive abnormalities. These results suggest that certain cognitive ...Continue Reading

References

Jun 1, 1978·The Journal of Nervous and Mental Disease·R K HeatonR A Lehman
Apr 1, 1977·Perceptual and Motor Skills·D M Gronwall
Oct 1, 1992·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·J C BeckhamW B Brook
Apr 1, 1992·Arthritis and Rheumatism·E M HayP J Holt
Jun 1, 1992·The Psychiatric Clinics of North America·W G Barr, M P Merchut
Jan 1, 1991·Psychotherapy and Psychosomatics·E M WekkingA J Swaak
Apr 1, 1990·Annals of the Rheumatic Diseases·A A LongJ A Denburg
Jan 1, 1990·Psychosomatics·W D Mitchell, T L Thompson
Jul 30, 1987·The New England Journal of Medicine·E BonfaK B Elkon
Aug 1, 1986·Arthritis and Rheumatism·E Bonfa, K B Elkon
Aug 1, 1987·Journal of Clinical and Experimental Neuropsychology·S D DenburgJ A Denburg
Jun 1, 1986·The Journal of Nervous and Mental Disease·R M CarbotteJ A Denburg
Dec 1, 1985·Journal of Consulting and Clinical Psychology·K M Adams, R K Heaton
Jan 1, 1984·Arthritis and Rheumatism·M H LiangP H Schur
Aug 1, 1981·Seminars in Arthritis and Rheumatism·J M KremerR J Silver
Jul 1, 1982·Arthritis and Rheumatism·H G Bluestein, V L Woods
Jul 1, 1982·Arthritis and Rheumatism·N J Zvaifler, H G Bluestein
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Mar 1, 1994·Arthritis and Rheumatism·L S Teh, D A Isenberg
Jul 1, 1993·Journal of Clinical and Experimental Neuropsychology·M M SalingP F Bladin
Jan 1, 1986·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·R M RuffL F Marshall

❮ Previous
Next ❯

Citations

Mar 31, 2010·Neuropsychology Review·Christopher M Filley
Jan 31, 2004·Journal of the International Neuropsychological Society : JINS·Janet L ShucardJulian Ambrus
Feb 3, 2009·Nature Clinical Practice. Rheumatology·Deborah M LevyLaura E Schanberg
Aug 23, 2002·Current Opinion in Rheumatology·Melanie J Harrison, Lisa D Ravdin
Sep 22, 2005·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Elizabeth KozoraJack H Simon
Jun 21, 2011·Biological Reviews of the Cambridge Philosophical Society·Angela Gallo, Franco Locatelli
May 17, 2007·Arthritis Research & Therapy·Elizabeth KozoraSterling West
Jun 23, 2000·Applied Neuropsychology·R L SkeelG R Komatireddy
Jan 17, 2013·The Journal of Rheumatology·So Young ShinPatricia Katz
Jun 28, 2012·International Journal of Clinical Rheumatology·Grace E Ahn, Rosalind Ramsey-Goldman
Dec 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Czeslawa KowalBetty Diamond
Mar 30, 2006·Current Rheumatology Reports·Melanie J Harrison, Lisa D Ravdin
Dec 17, 2005·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Nicholas A DoningerTammy O Utset
Aug 14, 1997·Annals of the New York Academy of Sciences·S D DenburgJ A Denburg
May 18, 2010·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Doruk ErkanMichael D Lockshin
Jan 5, 2005·European Journal of Pain : EJP·Fiona J DentonLeslie Schrieber
May 1, 2009·Arthritis and Rheumatism·Simone AppenzellerLilian T L Costallat
Nov 8, 2008·Annals of the New York Academy of Sciences·Jeremy D SchmahmannChristopher M Filley
Nov 1, 2008·Arthritis and Rheumatism·Elizabeth KozoraChristopher M Filley
Feb 18, 2012·Arthritis Care & Research·Patricia KatzLindsey A Criswell
Apr 1, 2011·Arthritis Care & Research·Laura J JulianPatricia P Katz
Jun 10, 2011·Acta Neurologica Scandinavica·B M SegalK L Moser
Jul 1, 2010·Arthritis Care & Research·Gail S RossUNKNOWN Childhood Arthritis & Rheumatology Research Alliance Ad-Hoc Neurocognitive Lupus Committee
Oct 27, 2006·Joint, Bone, Spine : Revue Du Rhumatisme·Alessandra Bruns, Olivier Meyer
Sep 10, 2005·Best Practice & Research. Clinical Rheumatology·John G Hanly, Melanie J Harrison
Jun 17, 2015·Biomarkers in Medicine·Tamar B RubinsteinBeatrice Goilav

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.