PMID: 9535504Apr 16, 1998Paper

Analysis of colchicine-induced chromosomal aberrations in embryos obtained from XO mice

Reproductive Toxicology
H Ishikawa, A Endo

Abstract

A high incidence of chromosomal anomalies has been observed in the offspring of our XO mouse colony. However, the reason(s) are unknown. We hypothesized that XO dams might be more susceptible to certain chromosomal mutagens. Therefore, we assessed whether the oocytes of XO mice are more susceptible to colchicine. Pregnant XO and XX mice were intraperitoneally (i.p.) injected with colchicine, 0.2 mg/kg, 6 h after mating (between resumption of meiosis II and extrusion of the second polar body). Contrary to our expectation, the incidence of chromosomal anomalies induced by colchicine exposure did not differ between XX and XO dams. These findings suggest that the chromosomal stability of the oocytes from XO mice may not be affected by colchicine exposure at the stage of extrusion of the second polar body. The effects of chromosomal imbalance inherent in XO mice on chemical susceptibilities should be further investigated.

References

Nov 18, 1976·Nature·N Takagi, M Sasaki
Jan 1, 1992·Reproductive Toxicology·K Omoe, A Endo
Feb 1, 1991·Genome Génome / Conseil National De Recherches Canada·A EndoT Fujita
Jan 1, 1989·Cytogenetics and Cell Genetics·A Endo, T Watanabe
Nov 1, 1989·Teratology·A Endo, T Watanabe
Jan 1, 1987·Environmental and Molecular Mutagenesis·J B Mailhes, Z P Yuan
Apr 1, 1986·Human Genetics·F BeermannI Hansmann
Jan 1, 1986·Mutation Research·C Tease, G Fisher
Jan 1, 1985·American Journal of Physical Anthropology·J H Relethford, D C Hodges
Dec 1, 1985·The Journal of Experimental Zoology·T MagnusonC J Epstein
Apr 1, 1973·Genetical Research·M F Lyon, S G Hawker
Oct 1, 1968·Genetical Research·T Morris
Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histology·A Gropp
Jan 1, 1983·Cytogenetics and Cell Genetics·P A Martin-DeLeon, M L Boice

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.