Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus.

European Journal of Clinical Pharmacology
Mateusz KurzawskiMarek Droździk

Abstract

New-onset diabetes after transplantation (NODAT) is a major complication after kidney transplantation. The risk factors for NODAT include the use of calcineurin inhibitors as part of the immunosuppressive regimen, among which tacrolimus has the most pronounced diabetogenic effect. Both NODAT and type 2 diabetes mellitus (T2DM) share several risk factors. Recent studies have identified a number of common genetic variants associated with increased risk of T2DM. Here we report the results of our study on the potential effect of single nucleotide polymorphisms (SNPs) previously associated with T2DM on the risk of NODAT in kidney transplant patients medicated with tacrolimus. Seven SNPs in six genes known to increase the risk of T2DM in Caucasians were genotyped by means of TaqMan assays in 235 kidney transplant patients medicated with tacrolimus: rs4402960 and rs1470579 in IGF2BP2; rs1111875 in HHEX; rs10811661 upstream of CDKN2A/B; rs13266634 in SLC30A8; rs1801282 in PPARG; rs5215 in KCNJ11. The TCF7L2 rs7903146 SNP was also included in the multivariate analysis. None of the analyzed SNPs was significantly associated with the risk of NODAT. However, the IGF2BP2 rs4402960 T allele was present significantly more frequently among pat...Continue Reading

References

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Citations

Oct 9, 2015·Journal of Diabetes Research·Polin HaghvirdizadehBatoul Sadat Haerian
Oct 18, 2012·Islets·Piero MarchettiLorella Marselli
May 9, 2016·Diabetologia·Yahui KongLaura C Alonso
Mar 30, 2017·The Pharmacogenomics Journal·P LanciaE Jacqz-Aigrain
Dec 29, 2017·The Pharmacogenomics Journal·Núria Saigi-MorguiUNKNOWN Swiss Transplant Cohort Study
Dec 7, 2013·Journal of the American Society of Nephrology : JASN·Jennifer A McCaughanAlexander P Maxwell
Dec 10, 2015·Endocrine Reviews·Vijay ShivaswamyJennifer Larsen
Jul 6, 2014·Molecular Biology Reports·Zahra ParviziMohamad Mehdi Parvizi
Jan 10, 2019·Archives of Endocrinology and Metabolism·Camila LimaRenato Nisihara
Nov 12, 2018·Clinical Pharmacokinetics·Camille TronEric Bellissant
Nov 29, 2020·Endocrine Reviews·Mamatha BhatMinna Woo
Apr 13, 2021·Endocrine Reviews·John T WalkerAlvin C Powers

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

Statistica
NODAT

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