PMID: 7543936Apr 1, 1995Paper

Analysis of connections between nitric oxide synthase neurons in the myenteric plexus of the guinea-pig small intestine

Journal of Neurocytology
H M YoungJ M Povey

Abstract

In the myenteric plexus of the guinea-pig ileum, a sub-population of descending interneurons contains nitric oxide synthase. Final neurons in descending motility pathways, inhibitory circular muscle motor neurons, also contain nitric oxide synthase. In this study we used ultrastructural immunocytochemistry to determine whether nitric oxide synthase descending interneurons provide inputs to all nitric oxide synthase neurons. The presence of nitric oxide synthase inputs to 35 nitric oxide synthase nerve cells from three animals was examined. Nine nerve cells from one ganglion were studied in serial section. Every nerve cell received inputs (close contacts and synapses) from nitric oxide synthase terminals. The number of inputs to the nine serially sectioned neurons ranged from 13 to 45. The inputs were found in about equal numbers on the cell bodies and the dendrites. There was no significant correlation between the size of nitric oxide synthase neurons and the number of nitric oxide synthase inputs they received. There was also no correlation between the number of nitric oxide synthase inputs and the number of 5-hydroxytryptamine inputs (determined in a previous study) received by nitric oxide synthase neurons. Random sections t...Continue Reading

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Citations

Jan 23, 1999·Journal of the Autonomic Nervous System·S Morikawa, T Komuro
Dec 2, 1999·Journal of the Autonomic Nervous System·Z K KrowickiP J Hornby
Mar 7, 2012·Nature Reviews. Gastroenterology & Hepatology·John B Furness
Apr 1, 1999·Annual Review of Physiology·W A Kunze, J B Furness
Mar 5, 2013·The Journal of Clinical Investigation·Ryo HottaHeather M Young
Mar 29, 2013·Autonomic Neuroscience : Basic & Clinical·Raj K Goyal, Arun Chaudhury
Jun 23, 2009·Journal of Cellular and Molecular Medicine·Marlene M Hao, Heather M Young
Dec 19, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K B Neal, J C Bornstein
Jan 30, 2014·Clinical and Experimental Pharmacology & Physiology·Jordan D ChambersJoel C Bornstein
Mar 27, 2018·The Journal of Comparative Neurology·D J SmoliloNick J Spencer
Oct 27, 2010·Cells, Tissues, Organs·Julia SchuyAxel Brehmer
Aug 7, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·John R Grider
Feb 8, 2000·The Journal of Comparative Neurology·A E LomaxJ B Furness
Sep 6, 2020·Cell·Eugene DrokhlyanskyAviv Regev

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