Analysis of continuous infusion functional PET (fPET) in the human brain.

Shenpeng LiZhaolin Chen


Functional positron emission tomography (fPET) is a neuroimaging method involving continuous infusion of 18-F-fluorodeoxyglucose (FDG) radiotracer during the course of a PET examination. Compared with the conventional bolus administration of FDG in a static PET scan, which provides an average glucose uptake into the brain over an extended period of up to 30 ​min, fPET offers a significantly higher temporal resolution to study the dynamics of glucose uptake. Several earlier studies have applied fPET to investigate brain FDG uptake and study its relationship with functional magnetic resonance imaging (fMRI). However, due to the unique characteristics of fPET signals, modelling of the fPET signal is a complex task and poses challenges for accurate interpretation of the results from fPET experiments. This study applied independent component analysis (ICA) to analyse resting state fPET data, and to compare the performance of ICA and the general linear model (GLM) for estimation of brain activation in response to tasks. The fPET signal characteristics were compared using GLM and ICA methods to model fPET data from a visual activation experiment. Our aim was to evaluate GLM and ICA methods for analysing task fPET datasets, and to appl...Continue Reading


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