PMID: 29288619Dec 31, 2017Paper

Analysis of CYP2C19 Genetic Polymorphism in a Large Ethnic Hakka Population in Southern China

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Zhixiong ZhongPingsen Zhao

Abstract

BACKGROUND Cytochrome P450 (CYP) 2C19 is an enzyme involved in the bioactivation of various important therapeutic drugs, from pro-drugs to an active inhibitor of platelet action. Variants in the CYP2C19 gene influence the pharmacokinetics and clinical response to antiplatelet drugs such as clopidogrel; however, there is no available data about the genetic variation of CYP2C19 in the Hakka population in China. MATERIAL AND METHODS A total of 6686 unrelated participants (ages 17-98 years) of self-reported Hakka ancestry admitted at an inpatient department in a hospital in southern China were successfully genotyped by the gene chip platform. RESULTS The identified allele frequencies were CYP2C19*1 (64.33%), *2 (31.06%) and *3 (4.61%). The major prevalent genotype combinations were CYP2C19 *1/*1 (41.73%) and *1/*2 (39.65%). The distribution of CYP2C19 phenotypes was divided into extensive metabolizers (EM) (41.73%), intermediate metabolizers (IM) (45.21%), and poor metabolizers (PM) (13.06%). In the Hakka population, frequencies of the CYP2C19 *2 and *3 variants were observed to be close to those previously identified in Chinese and several other Asian populations. CONCLUSIONS Our study is the first to report on CYP2C19 polymorphis...Continue Reading

Citations

Sep 2, 2020·European Journal of Hospital Pharmacy. Science and Practice·Cangsang SongYang Zhang
Nov 26, 2020·Clinical Drug Investigation·Chia Siang KowSyed Shahzad Hasan
Oct 29, 2020·Arquivos brasileiros de cardiologia·Ricardo SteinFilipe Ferrari
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammed Ahmed AkkaifBaharudin Ibrahim
May 7, 2021·Pharmacogenomics and Personalized Medicine·Lorena Díaz-OrdóñezHarry Pachajoa

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