Analysis of cytological changes in hepatocytes from rats dosed with 3'-methyl-4-dimethylaminoazobenzene: initial response appears to involve cytokinesis of binucleated cells

Cancer Letters
M KellyN Pritchard

Abstract

The reduction in the ratio of tetraploid (4N + 2 X 2N) to diploid (2N) hepatocytes in the adult rat after treatment with the hepatocarcinogen 3'-methyl-4-dimethylaminoazobenzene (3'M) has been investigated. Analysis of isolated hepatocytes 18-28 days after treatment has confirmed that initially some of the 2 X 2N hepatocytes are converted into 2N cells by cytokinesis, and that there is no DNA synthesis during this process. Shortly afterwards nonpolyploidizing growth commences by proliferation of some 2N cells.

References

Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C A SattlerH C Pitot
Aug 17, 1988·Journal of the National Cancer Institute·G SaeterO Seglen
Aug 1, 1958·Experimental Cell Research·M ALFERT, I I GESCHWIND

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Citations

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·K Aterman
May 28, 2013·Biochimica Et Biophysica Acta·Aleksandar SokolovićMilka Sokolović
Dec 1, 1993·Environmental Health Perspectives·J A Styles

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