Analysis of cytotoxic T lymphocyte associated antigen 4 gene polymorphisms in patients with ulcerative colitis

Journal of Gastroenterology and Hepatology
Kamran B LankaraniAbbas Ghaderi

Abstract

Ulcerative colitis (UC) is a multifactorial disease associated with dysregulated immunity. Recently, cytotoxic T lymphocyte associated antigen 4 (CTLA-4) gene polymorphisms have been reported in association with several autoimmune diseases in several populations. In the present study, the possible implication of the CTLA-4 gene as a risk factor for UC in the Iranian population was investigated. One hundred UC patients and 100 healthy subjects were studied. CTLA-4 exon 1 position 49 (A/G: codon 17: Thr/Ala) polymorphisms were investigated by polymerase chain reaction single strand confirmation polymorphism method. Four of the patients and one of the healthy controls were excluded from the study because of incomplete DNA extraction. The allele frequencies of A and G in 96 patients (A: 66.1%; G: 33.9%) were not significantly different from the 99 control subjects (A: 63.1%; G: 36.9%, P > 0.05). No significant differences in the distribution of genotype frequencies were observed between A + 49G gene polymorphisms and UC in the Iranian population (P > 0.05). CTLA-4 polymorphism is not associated with UC in the Iranian population.

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Citations

Jan 13, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Heather A Arnett, Joanne L Viney
Apr 27, 2011·International Journal of Colorectal Disease·Veronika CsöngeiBéla Melegh
Feb 21, 2009·World Journal of Gastroenterology : WJG·Jun YunBo-Rong Pan
Jan 1, 2014·World Journal of Gastroenterology : WJG·Kamran B LankaraniShima Hassanpour
Jul 2, 2009·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Walid Ben AlayaKhaled Ayed
Mar 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Salvatore Maria CorselloFrancesco Torino
Sep 18, 2015·World Journal of Gastroenterology : WJG·Jia-Jun ZhaoHong-Yu Li

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