Analysis of dendritic cells in tumor-free and tumor-containing sentinel lymph nodes from patients with breast cancer

Breast Cancer Research : BCR
Nancy J PoindexterE Grimm

Abstract

Sentinel lymph node (SLN) biopsy allows identification of the first lymph node into which a primary tumor drains. In breast cancer, identification of tumor cells in the SLNs is a predictor of the tumor's metastatic potential. In the present article, we tested the hypotheses that a positive immune response can occur in tumor-free SLNs and that the activation state of dendritic cells (DCs), the major antigen presenting cells within SLNs, predicts the immune status and metastatic potential of the tumor. Fifty paraffin-embedded SLN sections, 25 tumor-free and 25 tumor-containing, from patients with breast cancer were analyzed by immunohistochemistry to determine the immune maturation state of their DCs. In addition, 12 lymph nodes from noncancer-containing breasts were analyzed. Tissues were stained with antibodies against CD3, MHC class II, CD1a, CD83, IL-10, and IL-12. Mature DCs were defined by CD83 expression and immature DCs by CD1a expression. We found a trend toward higher numbers of mature CD83-positive DCs in tumor-free SLNs than in tumor-containing SLNs (P = 0.07). In addition, tumor-free SLNs were more likely to contain cells expressing IL-10 (P = 0.02) and, to a lesser extent, IL-12 (P = 0.12). In contrast, when all SLN...Continue Reading

References

Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·L J Zhou, T F Tedder
Feb 1, 1997·Current Opinion in Immunology·M CellaA Lanzavecchia
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A E GiulianoR Statman
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Apr 13, 1999·European Journal of Nuclear Medicine·Y ChuB A Fox
Jun 29, 2001·Trends in Immunology·H JonuleitA H Enk
Feb 9, 2002·Annals of Surgical Oncology·Stanley P L LeongJohn W C Chang
Jan 18, 2003·International Journal of Cancer. Journal International Du Cancer·Mitsuhiko IwamotoNobuhiko Tanigawa
Apr 25, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J-P TravagliR Rouzier

❮ Previous
Next ❯

Citations

Mar 15, 2011·Cancer Immunology, Immunotherapy : CII·Kristin H HaraldsdóttirKarl-G Tranberg
Dec 15, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Aaron S MansfieldSvetomir N Markovic
Sep 1, 2007·Annals of Surgical Oncology·Sang Uk WooYoung Kee Shin
Jul 25, 2008·Journal of Cancer Research and Clinical Oncology·Leticia Llanes-FernándezCristina Rodríguez-Padilla
Aug 26, 2006·Nature Reviews. Immunology·Alistair J CochranRichard Essner
Sep 19, 2009·Expert Review of Anticancer Therapy·Ana Paula de Souza, Cristina Bonorino
Jul 1, 2016·BMC Bioinformatics·E Andres HousemanCarmen J Marsit
Sep 19, 2006·Veterinary Immunology and Immunopathology·Agnès JaminGaëlle Kuntz-Simon
Oct 5, 2007·International Journal of Surgical Pathology·Cleverson Teixeira SoaresLaurival Antonio de Luca
Oct 14, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P Pelin KaraAysegul Uner
Jul 6, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rahul Kushwah, Jim Hu
Jan 23, 2015·The Cancer Journal·Alistair J CochranDuan-Ren Wen
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manabu ItoJun-ichi Ogawa
Sep 3, 2013·Cellular Oncology (Dordrecht)·Yesim Gökmen-PolarSunil Badve
Jan 25, 2011·Pathology Oncology Research : POR·Hossein GolmoghaddamMehrnoosh Doroudchi
Oct 16, 2018·Frontiers in Immunology·Antigoni PoultsidiConstantinos Petrovas
Jan 29, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Siping MinRongcun Yang
Mar 19, 2009·The Breast Journal·Huiying HePeiguo G Chu
Nov 9, 2012·International Journal of Cancer. Journal International Du Cancer·Neta S ZuckermanPeter P Lee
Jul 1, 2020·Nature Communications·Nicolas Gonzalo NúñezEliane Piaggio
May 8, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark IbbersonMarie-Agnès Doucey
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bruce ElliottUNKNOWN European Organization for Research and Treatment of Cancer Melanoma Group
Mar 21, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ángela QuintanaJavier Cortés
May 28, 2021·The American Journal of Pathology·Samir JanaDennis Jones

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.