Analysis of differences in outcome of two European liver transplant centers

Transplant International : Official Journal of the European Society for Organ Transplantation
B NemesMaarten J H Slooff

Abstract

Authors analyzed the differences in the outcome of two European liver transplant centers differing in case volume and experience. The first was the Transplantation and Surgical Clinic, Semmelweis University, Budapest, Hungary (SEB) and the second the University Medical Center Groningen, Groningen, The Netherlands (UMCG). We investigated if such differences could be explained. The 1-, 3- and 5-year patient survival in the UMCG was 86%, 80%, and 77% compared with 65%, 56%, and 55% in SEB. Graft survival at the same time points was 79%, 71%, and 66% in the UMCG and 62%, 55%, and 53% in SEB. Significant differences were present regarding the donor and recipient age, diagnosis mix, disease severity and operation variables, per-operative transfusion rate, vascular complications, postoperative infection rate, and need for renal replacement. To determine factors correlating with survival, a separate uni- and multivariate analysis was performed in each center individually, between study parameters and patient survival. In both centers, peri-operative red blood cell (RBC) transfusion rate was a significant predictor for patient survival. The difference in blood loss can be explained by different operation techniques and shorter operation...Continue Reading

References

Mar 1, 1990·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·M J SlooffD Van der Waaij
Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R A KromM J Slooff
Jan 1, 1993·Transplant International : Official Journal of the European Society for Organ Transplantation·J PruimM J Slooff
Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·B H Ferraz-NetoP McMaster
Jan 1, 1997·Transplant International : Official Journal of the European Society for Organ Transplantation·L J KlompmakerM J Slooff
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Nov 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·S H BelleK C Beringer
Feb 7, 1998·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·A SeilerM W Büchler
Aug 15, 1998·Transplant International : Official Journal of the European Society for Organ Transplantation·T KokI J Klompmaker
Dec 30, 1999·The New England Journal of Medicine·E B EdwardsL G Hunsicker
May 20, 2000·The New England Journal of Medicine·D J Hillebrand, W Concepcion
Jun 13, 2000·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·H G HendriksJ T de Wolf
Dec 9, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·A R MuellerP Neuhaus
Nov 8, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J BelghitiO Farges
Apr 12, 2002·The New England Journal of Medicine·John D BirkmeyerDavid E Wennberg
May 3, 2003·Transplant International : Official Journal of the European Society for Organ Transplantation·Janos FazakasFerenc Perner
Jul 19, 2003·Clinical Transplantation·Tamás Mándli, Tibor Gondos
Nov 8, 2003·Critical Care Medicine·J H Zwaveling
May 19, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·David A AxelrodRobert M Merion
Feb 11, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·B NemesJ Járay
Feb 18, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·H G D HendriksM J H Slooff
Jun 21, 2005·Transplantation Proceedings·B NemesL Kóbori

❮ Previous
Next ❯

Citations

May 10, 2008·Journal of Gastroenterology and Hepatology·Tsung-Ming ChenJai-Nien Tung
Dec 10, 2013·Transplantation Proceedings·B NemesL Kobori
Apr 29, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sheung Tat FanBanny K Lam
Feb 1, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alexander B BensonMarc Moss
Oct 13, 2007·Orvosi hetilap·Balázs NemesGabriella Lengyel
Oct 16, 2016·Transplantation Proceedings·M Szabo-PapB Nemes
May 31, 2011·Transplantation Proceedings·B NemesR M Langer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
K W LeeR A Montgomery
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
R B FreemanR M Merion
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
René AdamEuropean Liver Transplant Association
© 2022 Meta ULC. All rights reserved