PMID: 11933894Apr 6, 2002Paper

Analysis of digital scanning laser ophthalmoscopy fundus autofluorescence images of geographic atrophy in advanced age-related macular degeneration

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Steffen Schmitz-ValckenbergFAM Study Group

Abstract

Fundus autofluorescence (AF) imaging using confocal scanning laser ophthalmoscopy (cSLO) has been shown to be superior to fundus photography or angiography for delineating areas of geographic atrophy (GA) in retinal pigment epithelium (RPE) and for recording variation over time. We have evaluated a method for automated computerized detection and quantitation of RPE atrophy. AF images in vivo were recorded with a confocal scanning laser ophthalmoscope (exc. 488 nm, em. >500 nm; Heidelberg Retina Angiograph). The intensity of AF in atrophic areas was markedly decreased. Two independent readers analysed these areas in 24 right eyes manually by outlining GA areas using a mouse-driven arrow (method A) and automatically by image analysis software (Global Lab Image/2) after subjective adjustment of thresholding (method B). Agreement between observers and between methods A and B was assessed by the Bland-Altman design for method-comparison studies. Larger areas were measured using method A than B by both readers (agreement A/B: reader 1 mean difference 1.04 mm, 95% CI [0.66,1.42]; reader 2 mean difference 0.62 mm, 95% CI [0.43,0.81]). The agreement between the readers was mean difference 0.39 mm (95% CI [0.02,0.76]) for A and mean diff...Continue Reading

Citations

Dec 31, 2004·Optometry : Journal of the American Optometric Association·Victoria L DzurinkoJason R Price
May 10, 2003·Journal of Clinical Laser Medicine & Surgery
Apr 4, 2013·Investigative Ophthalmology & Visual Science·Wai T WongEmily Y Chew
Nov 23, 2010·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M FleckensteinS Schmitz-Valckenberg
Apr 30, 2013·Ophthalmology·Hilary Smolen BraderUNKNOWN Complications of Age-Related Macular Degeneration Prevention Trial (CAPT) Research Group
Apr 24, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Arno P GöbelSteffen Schmitz-Valckenberg
May 15, 2015·Ophthalmic Surgery, Lasers & Imaging Retina·Zohar YehoshuaPhilip J Rosenfeld
Oct 3, 2015·Ophthalmic Surgery, Lasers & Imaging Retina·Muneeswar G NittalaSrinivas R Sadda
Jan 28, 2009·Survey of Ophthalmology·Steffen Schmitz-ValckenbergFrank G Holz
Nov 22, 2007·Survey of Ophthalmology·Hannah Bartlett, Frank Eperjesi
Oct 25, 2016·Ophthalmology·Amitha DomalpallyUNKNOWN Age-Related Eye Disease Study 2 Research Group
Aug 26, 2011·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Arno P GöbelFrank G Holz
Jul 1, 2008·Retinal Cases & Brief Reports·Janet S Sunness
Sep 24, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Janet R SparrowJilin Zhou
Jan 24, 2007·International Ophthalmology Clinics·Rishi Singh, Peter K Kaiser
Jan 1, 2014·Journal of Clinical Medicine·Janet R Sparrow, Tobias Duncker
Jul 11, 2006·Retina·Janet S SunnessCarol A Applegate
Aug 24, 2016·Retina·Steffen Schmitz-ValckenbergUNKNOWN CAM (Classification of Atrophy Meeting)-Group
Dec 22, 2020·Ophthalmology Retina·Malini Veerappan PasrichaUNKNOWN Age-Related Eye Disease Study 2 Ancillary Spectral-Domain Optical Coherence Tomography Study Group
Aug 27, 2021·Translational Vision Science & Technology·Raziyeh MahmoudzadehJason Hsu

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