Analysis of doramectin in the serum of repeatedly treated pastured cattle used to predict the probability of cattle fever ticks (Acari: Ixodidae) feeding to repletion.

Experimental & Applied Acarology
Ronald B DaveyPia U Olafson

Abstract

Analysis of doramectin concentration in blood serum of pastured cattle injected repeatedly (12 treatments) at two different dosage rates and 28-day intervals throughout the year was used to predict the probability that cattle fever ticks could successfully feed to repletion during the interval between any two consecutive treatments. Treatment at ~270 μg/kg indicated that serum doramectin concentration dropped below the baseline concentration estimated for tick survival (8 ppb) in 7 of the 12 treatments. However, the longest period between any two treatments during which the doramectin concentration remained below the 8 ppb baseline level for successful tick feeding was 15 days, making it virtually impossible for any ticks to reach ovipositional status prior to a subsequent treatment. At a dosage rate of ~540 μg/kg, the concentration dropped below the baseline tick survival level (8 ppb) only once, following the initial treatment, and the duration during which the concentration remained below the baseline level prior to the subsequent treatment was only 6 days. Thus, at the high dosage rate results indicated, with absolute certainty, that no ticks could successfully feed to repletion between any two consecutive treatments. Based...Continue Reading

References

Jun 20, 1977·Journal of Medical Entomology·O H Graham, J L Hourrigan
May 1, 1989·Journal of Medical Entomology·L M CookseyJ E George
Nov 1, 1985·Australian Veterinary Journal·J NolanP Bird
Apr 1, 1997·Journal of Veterinary Pharmacology and Therapeutics·C LanusseM Alvinerie
Dec 24, 1997·Veterinary Parasitology·P L ToutainM E McKenzie

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