Analysis of Drug-Drug Interactions in Swiss Claims Data Using Tizanidine and Ciprofloxacin as a Prototypical Contraindicated Combination

The Annals of Pharmacotherapy
Annika M JödickeMarco Egbring

Abstract

Potential drug-drug interactions (pDDIs) are described in various case reports, but few studies have evaluated the impact of specific combinations on a population level. To analyze the type and frequency of multiple contraindicated (X-pDDIs) and major interactions (D-pDDIs) and to subsequently assess the impact of the particular combination of tizanidine and ciprofloxacin on outpatient physician visits and hospitalizations. Anonymized Swiss claims data from 524 797 patients in 2014-2015 were analyzed. First, frequencies of X- and D-pDDIs were calculated. Next, a retrospective cohort study was conducted among patients prescribed tizanidine and ciprofloxacin (exposed, n = 199) or tizanidine and other antibiotics (unexposed, n = 960). Hospitalizations and outpatient physician visits within 7, 14, and 30 days after initiation of antibiotic therapy were evaluated using multiple binary logistic regression and multiple linear regression. The relative frequencies of X- and D-pDDIs were 0.4% and 6.65%, respectively. In the cohort study, significant associations between exposure to tizanidine and ciprofloxacin and outpatient physician visits were identified for 14 and 30 days (odds ratio [OR] = 1.61 [95% CI = 1.17-2.24], P = 0.004, and O...Continue Reading

References

Oct 9, 2003·Scandinavian Journal of Primary Health Care·Lars BjerrumJakob Kragstrup
Sep 22, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Daniel C MaloneRichard B Lipton
Dec 13, 2006·Pharmacoepidemiology and Drug Safety·Matthijs L BeckerBruno H Ch Stricker
Dec 21, 2006·Clinical Pharmacology and Therapeutics·Kenji MomoAkira Tamaoka
Dec 18, 2007·Research in Social & Administrative Pharmacy : RSAP·Rajender AparasuAnuradha Aparasu
Jan 14, 2010·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Cristiano Soares MouraNajara Oliveira Belo
Jul 14, 2010·Pharmacoepidemiology and Drug Safety·Florence T BourgeoisKenneth D Mandl
Jul 20, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Roberto LeoneAnita Conforti
Jan 19, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Alissa J WrightDavid N Juurlink
Sep 7, 2012·BMC Pharmacology & Toxicology·Elmira FarMarco Egbring
Oct 25, 2012·Clinical Pharmacology and Therapeutics·D PincusD N Juurlink
Mar 27, 2013·Clinical and Experimental Pharmacology & Physiology·Danijela Gnjidic, Kristina Johnell
Jun 20, 2013·Annals of Internal Medicine·Amit M PatelAmit X Garg
Mar 13, 2014·Pharmacoepidemiology and Drug Safety·Supinya DechanontChuenjid Kongkaew
Sep 6, 2014·European Journal of Clinical Pharmacology·Johan HolmBuster Mannheimer
Jul 4, 2015·Journal of Clinical Anesthesia·Alaa Abd-ElsayedWael Sakr
Oct 20, 2015·Clinical Pharmacology and Therapeutics·S HennessyW B Bilker
Jul 19, 2017·Research in Social & Administrative Pharmacy : RSAP·Janja JazbarMitja Kos

❮ Previous
Next ❯

Methods Mentioned

BETA
Pharmacotherapy

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.