Analysis of European mitochondrial haplogroups with Alzheimer disease risk

Neuroscience Letters
Joelle M van der WaltMargaret A Pericak-Vance

Abstract

We examined the association of mtDNA variation with Alzheimer disease (AD) risk in Caucasians (989 cases and 328 controls) testing the effect of individual haplogroups and single nucleotide polymorphisms (SNPs). Logistic regression analyses were used to assess risk of haplogroups and SNPs with AD in both main effects and interaction models. Males classified as haplogroup U showed an increase in risk (OR = 2.30; 95% CI, 1.03-5.11; P = 0.04) of AD relative to the most common haplogroup H, while females demonstrated a significant decrease in risk with haplogroup U (OR = 0.44 ; 95% CI, 0.24-0.80; P = 0.007). Our results were independent of APOE genotype, demonstrating that the effect of mt variation is not confounded by APOE4 carrier status. We suggest that variations within haplogroup U may be involved in AD expression in combination with environmental exposures or nuclear proteins other than APOE.

References

Aug 1, 1992·Journal of Neurochemistry·S J KishJ N Nobrega
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·D C Wallace
Oct 27, 1997·Neurology·R H SwerdlowW D Parker
Jan 23, 1999·American Journal of Human Genetics·V MacaulayA Torroni
May 12, 2001·Mechanisms of Ageing and Development·G De BenedictisA I Yashin
Oct 9, 2002·Neuropathology and Applied Neurobiology·D A CottrellD M Turnbull
Mar 6, 2003·American Journal of Human Genetics·Joelle M van der WaltJeffery M Vance
Jul 24, 2003·Neuroscience Letters·Sofia A OliveiraMargaret A Pericak-Vance

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Citations

Jan 29, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Larissa ArningAndrew Chan
Apr 22, 2005·International Journal of Legal Medicine·B BudowleM Allen
May 24, 2011·Journal of Neurology·Massimiliano FilostoAlessandro Padovani
Jan 13, 2006·Human Genetics·Joanna L ElsonNeil Howell
Jul 3, 2007·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·M MancusoL Murri
May 19, 2009·Behavior Genetics·Enda M ByrnePeter M Visscher
Feb 21, 2009·Journal of Inherited Metabolic Disease·A BonninM M Ramon
Mar 7, 2009·Breast Cancer Research and Treatment·Anna M CzarneckaJohn A Petros
Dec 23, 2006·Cellular and Molecular Neurobiology·Farzaneh FesahatFarzaneh Mirzajani
Oct 3, 2009·Journal of Bioenergetics and Biomembranes·Michelangelo MancusoLuigi Murri
Apr 30, 2005·Nature Reviews. Genetics·Robert W Taylor, Doug M Turnbull
Jul 1, 2005·The New England Journal of Medicine·Michael A SliferMargaret A Pericak-Vance
Aug 30, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Milena NasiAndrea Cossarizza
Sep 25, 2007·Antioxidants & Redox Signaling·Michelangelo MancusoGabriele Siciliano
Sep 18, 2007·Antioxidants & Redox Signaling·Kristina LeunerWalter E Müller
Sep 8, 2007·Antioxidants & Redox Signaling·Jose ViñaMaria-Dolores Alonso
Sep 10, 2011·Antioxidants & Redox Signaling·Louise HedskogMaria Ankarcrona
Dec 24, 2011·Genetic Testing and Molecular Biomarkers·Pablo Coto-SeguraEliecer Coto
Dec 21, 2006·Nucleic Acids Research·Eduardo Ruiz-PesiniDouglas C Wallace
Mar 18, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Yi YangJianghua Chen
Apr 3, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Sher L HendricksonStephen J O'Brien
Jul 10, 2009·Proceedings. Biological Sciences·François BallouxAndrea Manica
Aug 5, 2009·Genes & Development·Douglas C Wallace, Weiwei Fan
Nov 24, 2011·BMC Musculoskeletal Disorders·Mercedes Fernandez-MorenoFrancisco J Blanco
Dec 17, 2011·BMC Musculoskeletal Disorders·Mercedes Fernández-MorenoFrancisco J Blanco
Jan 9, 2009·Human Genomics·Michelangelo MancusoGabriele Siciliano
Feb 26, 2010·Molecular Neurodegeneration·Johanna KrügerAnne M Remes
Oct 30, 2009·International Archives of Medicine·Anna M CzarneckaEwa Bartnik
Mar 24, 2012·Neurology·G HudsonUNKNOWN GERAD1 Consortium

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