Analysis of expression of candidate genes for polycystic ovary syndrome in adult and fetal human and fetal bovine ovaries†.

Biology of Reproduction
Menghe LiuRaymond J Rodgers

Abstract

Polycystic ovary syndrome (PCOS) appears to have a genetic predisposition and a fetal origin. We compared the expression levels of 25 PCOS candidate genes from adult control and PCOS human ovaries (n = 16) using microarrays. Only one gene was potentially statistically different. Using qRT-PCR, expression of PCOS candidate genes was examined in bovine fetal ovaries from early stages when they first developed stroma through to completion of development (n = 27; 60-270 days of gestation). The levels of ERBB3 mRNA negatively correlated with gestational age but positively with HMGA2, FBN3, TOX3, GATA4, and DENND1A.X1,2,3,4, previously identified as correlated with each other and expressed early. PLGRKT and ZBTB16, and less so IRF1, were also correlated with AMH, FSHR, AR, INSR, and TGFB1I1, previously identified as correlated with each other and expressed late. ARL14EP, FDFT1, NEIL2, and MAPRE1 were expressed across gestation and not correlated with gestational age as shown previously for THADA, ERBB4, RAD50, C8H9orf3, YAP1, RAB5B, SUOX, and KRR1. LHCGR, because of its unusual bimodal expression pattern, had some unusual correlations with other genes. In human ovaries (n = 15; <150 days of gestation), ERBB3.V1 and ERBB3.VS were expr...Continue Reading

References

May 1, 1983·In Practice·R Barlow
Feb 1, 1982·Obstetrical & Gynecological Survey·P E Hughesdon
Feb 13, 2001·Fertility and Sterility·M D Kahsar-MillerR Azziz
Aug 3, 2002·Science·Hyun-Soo Cho, Daniel J Leahy
Mar 22, 2003·Experimental Cell Research·H Steven Wiley
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
Aug 17, 2004·Molecular Endocrinology·Erik JansenBart C J M Fauser
Sep 9, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Yi-Xun Liu
Oct 13, 2005·The Journal of Clinical Endocrinology and Metabolism·J M VinkD I Boomsma
Jul 27, 2006·The Journal of Clinical Endocrinology and Metabolism·D R StewartR S Spielman
Aug 26, 2006·Nature Reviews. Immunology·Kenya Honda, Tadatsugu Taniguchi
Jul 31, 2007·Reviews in Endocrine & Metabolic Disorders·Daniel A DumesicVasantha Padmanabhan
Apr 12, 2008·Cancer Gene Therapy·G Sithanandam, L M Anderson
Jan 27, 2009·International Journal of Cancer. Journal International Du Cancer·Alain G ZeimetChristian Marth
Mar 5, 2010·The Journal of Clinical Endocrinology and Metabolism·Kathryn G EwensRichard S Spielman
Mar 18, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nicholas HatzirodosRaymond J Rodgers
Feb 15, 2013·PloS One·Katja HummitzschRaymond J Rodgers
Mar 28, 2013·Seminars in Thrombosis and Hemostasis·Lindsey A Miles, Robert J Parmer
May 25, 2013·Steroids·Vasantha Padmanabhan, Almudena Veiga-Lopez
Jun 15, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Robert Roskoski
Jun 24, 2014·PloS One·Nicholas HatzirodosRaymond J Rodgers
Feb 13, 2016·Current Opinion in Endocrinology, Diabetes, and Obesity·Kirsty A Walters
May 18, 2016·Fertility and Sterility·Michelle R Jones, Mark O Goodarzi
Jun 2, 2016·DNA Repair·David SchuermannPrimo Schär
Jun 15, 2016·Molecular and Cellular Endocrinology·Meng Kian TeeWalter L Miller
Jul 9, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Daria LiznevaRicardo Azziz
Sep 14, 2016·Maturitas·Joop S E LavenJan H J Hoeijmakers
May 23, 2017·Human Reproduction Update·Panagiota Filippou, Roy Homburg
Aug 18, 2017·The Journal of Cell Biology·Chao YangAnna Akhmanova
Oct 14, 2017·Human Reproduction Update·Dulama Richani, Robert B Gilchrist
Feb 10, 2018·Nucleic Acids Research·Myriam KoubiEstelle Duprez
Mar 2, 2018·Journal of Thrombosis and Haemostasis : JTH·L A MilesR J Parmer
Jul 12, 2018·Obstetrics and Gynecology·Ricardo Azziz
Dec 7, 2018·Reproduction, Fertility, and Development·M D HartantiR J Rodgers
Mar 18, 2019·Reproductive Biology and Endocrinology : RB&E·Genia F BurchallTerrence J Piva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.