Analysis of expression of programmed cell death 1 ligand 1 (PD-L1) in malignant pleural mesothelioma (MPM)

PloS One
Susana CedrésEnriqueta Felip

Abstract

The increasing incidence and poor outcome associated with MPM requires finding effective treatment for this disease. PD1/PD-L1 pathway plays a central role in tumor immune evasion and appears to be predictive and prognostic marker. PD-L1 is expressed in many different human cancers but its role in MPM has yet to be established. The aim of this study is to evaluate the expression of PD-L1 in MPM. 119 MPM patients (p) from two institutions between November 2002 and February 2014 were reviewed. Formalin-fixed, paraffin-embedded tissue was stained with anti-PD-L1 (clone E1L3N). Cases showing more than 1% of tumor cells expression of PD-L1 were considered positive. PD-L1 was analyzed in 77 p with tumor tissue available and was positive in 20.7% p (14 samples in membrane, 16 in cytoplasm and 4 in immune infiltrate). PD-L1 intensity was weak in 56.2%, moderate in 25% and strong in 18.7% p. There was a significant relationship between PD-L1 expression and histology (PD-L1 expression 37.5% in no-epithelioid tumor and 13.2% in epithelioid; p=0.033). The median survival in p PD-L1 positive was 4.79 vs 16.3 months in p PD-L1 negative (p=0.012). We have shown PD-L1 is expressed in 20% of patients, associated with no epithelioid histology an...Continue Reading

References

Jan 1, 1987·The Annals of Thoracic Surgery·N MartiniB S Hilaris
Apr 28, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·B W RobinsonR A Lake
Oct 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G L CeresoliE Villa
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nicholas J VogelzangPaolo Paoletti
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun KonishiMasaharu Nishimura
Dec 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·R Houston ThompsonEugene D Kwon
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuichiro OhigashiYoshiyuki Nakajima
Jun 14, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Raja M Flores
Dec 23, 2006·The Annals of Thoracic Surgery·John E PillingPeter Goldstraw
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Junzo HamanishiShingo Fujii
Oct 3, 2007·The Medical Journal of Australia·Roger K A Allen
Jan 5, 2008·Annual Review of Immunology·Mary E KeirArlene H Sharpe
Feb 6, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Isabelle OpitzWalter Weder
Apr 1, 2008·The Journal of Thoracic and Cardiovascular Surgery·Masaki AnrakuMarc de Perrot
May 27, 2008·Nature Reviews. Immunology·Weiping Zou, Lieping Chen
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc de PerrotMichael R Johnston
Mar 3, 2009·The European Respiratory Journal·C JackamanD J Nelson
Aug 13, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert J KreitmanIra Pastan
Oct 15, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rezaul KarimSjoerd H van der Burg
Dec 17, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew J CurrieRobbert G van der Most
Jan 27, 2010·Cancer Science·Koichi InamiOkio Hino
Jun 23, 2010·Cancer Immunology, Immunotherapy : CII·Noriyuki YamadaMasaharu Nishimura
Nov 3, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raffit HassanDaniel Laheru
Mar 26, 2011·Journal of Surgical Oncology·Ottavio RenaCaterina Casadio
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jun 5, 2012·The New England Journal of Medicine·Julie R BrahmerJon M Wigginton
Mar 6, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mario Sznol, Lieping Chen
May 17, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Vamsidhar VelchetiKurt A Schalper
Jun 4, 2013·The New England Journal of Medicine·Omid HamidAntoni Ribas
Sep 21, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mario Sznol, Lieping Chen
Nov 13, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·Vamsidhar VelchetiDavid L Rimm
Feb 20, 2014·PloS One·Hatem SolimanScott Antonia
Mar 22, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kurt A SchalperDavid L Rimm
Jun 14, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Aaron Scott MansfieldEugene D Kwon

❮ Previous
Next ❯

Citations

Aug 27, 2015·Expert Review of Respiratory Medicine·Angela BononiMichele Carbone
Mar 17, 2016·Human Pathology·Christelle Combaz-LairSylvie Lantuejoul
Feb 5, 2016·Veterinary and Comparative Oncology·G HartleyS Dow
Oct 5, 2015·Cancer Treatment Reviews·Elly MarcqEvelien L J Smits
Mar 5, 2016·Expert Review of Anticancer Therapy·Laurel M SchunselaarPaul Baas
Jun 12, 2016·Journal of Translational Medicine·Woo Young SunJa Seung Koo
Sep 27, 2016·Expert Review of Anticancer Therapy·Bibhusal ThapaTom John
Jan 17, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Aaron Scott Mansfield
Jun 21, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Steven C KaoGlen Reid
Mar 31, 2018·International Journal of Molecular Sciences·Jorien Minnema-LuitingRobin Cornelissen
Mar 8, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G PaselloF Calabrese
Aug 18, 2017·British Journal of Cancer·Serena J CheeChristian H Ottensmeier
Sep 19, 2017·Cancer Cytopathology·Mohammed S I MansourAnnika Dejmek
Dec 21, 2017·Immunotherapy·Solenn BrosseauArnaud Scherpereel
Oct 7, 2017·Future Oncology·Navid SobhaniDaniele Generali
Jun 27, 2018·Cancer Immunology, Immunotherapy : CII·Luana CalabròMichele Maio
Nov 28, 2018·Human Vaccines & Immunotherapeutics·Julie M Collins, James L Gulley
Sep 5, 2019·Archives of Pathology & Laboratory Medicine·Fatemeh DerakhshanAndrew Churg
Sep 21, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Stephanie MullerJennifer L Sauter
Apr 12, 2020·Cancers·Fabio NicoliniMassimiliano Mazza
Feb 27, 2020·Journal for Immunotherapy of Cancer·Katsuyuki Hotta, Nobukazu Fujimoto
Jan 10, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S CedrésE Felip
May 3, 2019·Expert Opinion on Biological Therapy·Anna K NowakAlistair Cook
Nov 7, 2017·Asia-Pacific Journal of Clinical Oncology·Bella Hai NguyenSayed Ali
Jul 7, 2017·Current Treatment Options in Oncology·Maria M J DisselhorstPaul Baas
Mar 27, 2018·Journal of Cellular and Molecular Medicine·Ping-Chih HsuLiang You
Mar 15, 2019·Oncology Letters·Jianzhong Yang, Guangzhu Hu
Apr 1, 2020·Frontiers in Oncology·Luca CantiniJoachim G J V Aerts
Dec 24, 2019·Frontiers in Oncology·Gerard J ChuJohn E J Rasko
Oct 8, 2020·Pathology International·Eiji MatsumuraOkio Hino
Jul 17, 2019·Molecular Cancer Research : MCR·Zhaoji PanGuoping Niu
Aug 30, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paulino Tallón de LaraAlessandra Curioni-Fontecedro
Jun 6, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Morihito OkadaYuichiro Ohe

❮ Previous
Next ❯

Software Mentioned

R

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Ai zheng = Aizheng = Chinese journal of cancer
Ka-Jia Cao, Nian-Ji Cui
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Aaron Scott MansfieldEugene D Kwon
Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu
Zhixue ZhengJiafu Ji
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Yuki KatsuyaKoji Tsuta
Annals of Cardiothoracic Surgery
Christopher CaoRebecca Harris
© 2021 Meta ULC. All rights reserved