Analysis of Expression of Vascular Endothelial Growth Factor A and Hypoxia Inducible Factor-1alpha in Patients Operated on Stage I Non-Small-Cell Lung Cancer

Lung Cancer International
Antonio Francisco Honguero MartínezRicardo Guijarro Jorge

Abstract

Objectives. Recent studies show that expression of hypoxia inducible factor-1alpha (HIF-1α) favours expression of vascular endothelial growth factor A (VEGF-A), and these biomarkers are linked to cellular proliferation, angiogenesis, and metastasis in different cancers. We analyze expression of HIF-1α and VEGF-A to clinicopathologic features and survival of patients operated on stage I non-small-cell lung cancer. Methodology. Prospective study of 52 patients operated on with stage I. Expression of VEGF-A and HIF-1α was performed through real-time quantitative polymerase chain reaction (qRT-PCR). Results. Mean age was 64.7 and 86.5% of patients were male. Stage IA represented 23.1% and stage IB 76.9%. Histology classification was 42.3% adenocarcinoma, 34.6% squamous cell carcinoma, and 23.1% others. Median survival was 81.0 months and 5-year survival 67.2%. There was correlation between HIF-1α and VEGF-A (P = 0.016). Patients with overexpression of HIF-1α had a tendency to better survival with marginal statistical significance (P = 0.062). Patients with overexpression of VEGF-A had worse survival, but not statistically significant (P = 0.133). Conclusion. The present study revealed that VEGF-A showed correlation with HIF-1α. HIF...Continue Reading

References

Nov 18, 1971·The New England Journal of Medicine·J Folkman
Feb 2, 1996·The Journal of Biological Chemistry·A P LevyM A Goldberg
Jun 10, 2000·Medicina clínica·E FernándezC la Vecchia
Feb 22, 2001·Journal of the National Cancer Institute·M Höckel, P Vaupel
Sep 12, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M LiaoD Zhu
Sep 29, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·K Junker
Oct 9, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ken-ichiro MinamiAkiharu Okamura
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
Jun 7, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Seok Jin KimMichael J Kelley
Dec 20, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Roy M BremnesRafael Sirera
Jan 24, 2006·Cirugía española·Alfredo Paredes-LarioMiguel Echenique-Elizondo
May 6, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Sotarou EnatsuMasahide Kuroki
Aug 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Danny R YouldenPeter D Baade
Feb 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin ReckChristian Manegold
Jul 9, 2009·Chest·Frank C DetterbeckLynn T Tanoue
Aug 19, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ping ZhanYong Song
Feb 6, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Val R Adams, R Donald Harvey
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L CrinòUNKNOWN ESMO Guidelines Working Group
Sep 8, 2010·The European Respiratory Journal·A López-EncuentraUNKNOWN Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pneumology and Thoracic Surgery (GCCB-S)
Aug 16, 2011·Journal of Surgical Oncology·Min Jung KimJae Yong Park
Dec 14, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Wu-Hsien KuoYao-Ling Lee

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
biopsy
dissection
surgical resection
electrophoresis
PCR
Assay

Software Mentioned

SPSS

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.