Analysis of Factors Driving Incident and Ascending Infection and the Role of Serum Antibody in Chlamydia trachomatis Genital Tract Infection

The Journal of Infectious Diseases
Ali N RussellToni Darville

Abstract

Chlamydia trachomatis genital tract infection is a major cause of female reproductive morbidity. Risk factors for ascending infection are unknown, and the role for antibody in protection is not well established. We recruited 225 women from urban outpatient clinics and followed them for a median of 12 months. We performed a cross-sectional analysis of serum anti-chlamydial immunoglobulin G (IgG), behavioral factors, and microbiological factors associated with endometrial infection at enrollment, and a longitudinal analysis of factors associated with incident infection. Oral contraceptives (adjusted relative risk [RR], 2.02 [95% confidence interval {CI}, 1.38-2.97]) and gonorrhea (adjusted RR, 1.66 [95% CI, 1.07-2.60]) were associated with endometrial infection. Gonorrhea (adjusted hazard ratio [HR], 3.09 [95% CI, 1.41-6.78]), cervical infection at enrollment (adjusted HR, 2.33 [95% CI, 1.07-5.11]), and exposure to uncircumcised partners (adjusted HR, 2.65 [95% CI, 1.21-5.82]) or infected partners (adjusted HR, 4.99 [95% CI, 2.66-9.39]) significantly increased the risk of incident infection. Seropositivity was associated with a reduced cervical burden (P < .05) but no differences in rates of ascending infection (adjusted RR, 1.24...Continue Reading

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Citations

Mar 14, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaojing ZhengToni Darville
Feb 10, 2018·The Journal of Infectious Diseases·Jay VornhagenLakshmi Rajagopal
Mar 2, 2019·The Journal of Infectious Diseases·Taylor B PostonXiaojing Zheng
Oct 9, 2018·Frontiers in Cellular and Infection Microbiology·Xiaojing ZhengToni Darville
Mar 5, 2020·Frontiers in Genetics·Wujuan ZhongXiaojing Zheng
Jan 1, 2020·Current Clinical Microbiology Reports·Amy Berry, Jennifer V Hall
Sep 23, 2020·Scientific Reports·Stephanie R LundyYusuf O Omosun
Dec 15, 2020·Biometrics·Wujuan ZhongYun Li
Mar 9, 2021·Expert Review of Vaccines·Luis M de la MazaSukumar Pal
May 30, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gloria E AnyalechiKyle T Bernstein
Aug 17, 2021·The Journal of Infectious Diseases·Xiaojing ZhengToni Darville

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