Analysis of factors influencing the generation of unqualified clinical samples and measures to prevent this generation.

Annals of Laboratory Medicine
Xiaofei LaiLiping Zhang

Abstract

We investigated the influence of pre-analytical factors on the results of clinical tests and thereby analyzed approaches to improve quality management in clinical laboratories. Unqualified clinical samples were selected from all the samples received at our clinical laboratory. The data were collected for 2009 and 2010, i.e., the years before and after the establishment of the laboratory quality management system. The rate and causes of generation of unqualified samples were analyzed, and measures to improve the laboratory practices were studied and implemented. A total of 1,051 unqualified samples were identified from among the 553,158 samples (the overall incidence rate of unqualified samples was 0.19%). The number of unqualified samples substantially varied according to the nature of the sample, and clinical samples collected for routine blood tests or coagulation tests were the predominant unqualified samples. The main causes of generation of unqualified samples were insufficient sample volumes and improper methods of mixing the samples. The rate of generation of unqualified samples decreased significantly after the implementation of improvement measures (0.26% in 2009 vs. 0.13% in 2010, P<0.001). The number of unqualified s...Continue Reading

References

Mar 25, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·G D Lundberg
Jul 10, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mario Plebani
Jul 21, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Carmen RicósBlanca de la Fuente
Nov 24, 2004·Clinics in Laboratory Medicine·Ana K Stankovic
Jun 1, 2005·Health Care Management Review·Patrick A RiversFrancesco A Germinario
Nov 1, 2005·Joint Commission Journal on Quality and Patient Safety·Sunita SaxenaStephanie Hall
Jun 27, 2006·Clinical Chemistry·Giuseppe LippiGian Cesare Guidi

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