Analysis of Fentanyl and 18 Novel Fentanyl Analogs and Metabolites by LC-MS-MS, and report of Fatalities Associated with Methoxyacetylfentanyl and Cyclopropylfentanyl

Journal of Analytical Toxicology
Melissa F FogartyBarry K Logan

Abstract

Methoxyacetylfentanyl and cyclopropylfentanyl are two of the newest illicit opioids that are infiltrating the heroin market. Methoxyacetylfentanyl and cyclopropylfentanyl were reported by the Drug Enforcement Administration (DEA) in their third quarter report of 2017 to have been chemically identified seven and five times, respectively, from drug evidence analyzed by the DEA's lab system; Q3 was the first time cyclopropylfentanyl was identified by the DEA's lab system, while methoxyacetylfentanyl was reported one time in Q2 2017. A method was developed using liquid chromatography tandem mass spectrometry for the quantitation of fentanyl, norfentanyl and 17 fentanyl analogs: furanylfentanyl, butyrylfentanyl, despropionylfentanyl (4-ANPP), methoxyacetylfentanyl, tetrahydrofuran fentanyl, fluoro-isobutyrylfentanyl, acrylfentanyl, para-fluorofentanyl, ortho-fluorofentanyl, carfentanil, beta-methylfentanyl, isobutyrylfentanyl, para-methylfentanyl, cyclopentylfentanyl, cyclopropylfentanyl, beta-hydroxyfentanyl and alpha-methylfentanyl. The calibration range for all compounds was 0.1-100 ng/mL. Blood samples from 42 postmortem cases involving cyclopropylfentanyl and methoxyacetylfentanyl from Florida, Illinois, Michigan and Tennessee ...Continue Reading

References

Nov 1, 1990·Journal of Analytical Toxicology·A K ChaturvediJ R Baird
Jul 1, 1988·Journal of Analytical Toxicology·R J Matejczyk
Nov 1, 1984·Journal of Analytical Toxicology·J C GarriottV J Di Maio
May 29, 2004·The American Journal of Forensic Medicine and Pathology·Amy M TharpDavid C Winston
Oct 6, 2016·Journal of Analytical Toxicology·Dayong LeeBruce A Goldberger
Mar 1, 2017·Academic Forensic Pathology·David R Fowler
Mar 1, 2017·Academic Forensic Pathology·David Dolinak

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Citations

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Feb 19, 2019·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Dieter MüllerMarcel Grapp
Oct 9, 2018·Journal of Analytical Toxicology·Wenche Rødseth BredeLars Slørdal
Nov 22, 2018·Journal of Analytical Toxicology·Alberto SalomoneMarco Vincenti
Jan 29, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Gabriella RodaMichele Dei Cas
Aug 21, 2019·Journal of Psychopharmacology·John M CorkeryAmy Hendricks
Sep 11, 2019·Journal of Analytical Toxicology·Svante VikingssonHenrik Gréen
Mar 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Peter J H ScottRonald B Moss
Feb 18, 2020·Journal of Analytical Toxicology·Kaitlyn B Palmquist, Madeleine J Swortwood
Apr 30, 2020·Journal of Analytical Toxicology·Courtney CastellinoRubi Cabrera
May 27, 2020·Journal of Analytical Toxicology·Matthew Di RagoDimitri Gerostamoulos
Jul 16, 2019·Forensic Sciences Research·Inês TabarraEugenia Gallardo
Jul 13, 2018·MMWR. Morbidity and Mortality Weekly Report·Julie O'DonnellMbabazi Kariisa
Feb 20, 2019·Substance Abuse Treatment, Prevention, and Policy·Ronald B Moss, Dennis J Carlo
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Aug 30, 2020·Journal of Analytical Toxicology·Pietro BrunettiAlfredo Fabrizio Lo Faro
Nov 27, 2020·Brain Sciences·Michael H BaumannAlex J Krotulski
Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Jan 2, 2021·Forensic Science International : Synergy·Wing-Sum ChanBobbie Kwok-Keung Cheung
Jan 9, 2021·Journal of Analytical Toxicology·Melissa M BudelierStephen M Roper
Oct 17, 2020·Analytical and Bioanalytical Chemistry·Alberto SalomoneMarco Vincenti
Jul 22, 2020·Journal of Pharmaceutical and Biomedical Analysis·Francesca FreniLuca Morini
Apr 3, 2021·The American Journal of Drug and Alcohol Abuse·Neeraj ChhabraSteven E Aks
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May 20, 2021·Journal of Analytical Toxicology·Kaitlyn B Palmquist, Madeleine J Swortwood
May 6, 2019·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Juseon LeeBarry K Logan
Jul 22, 2021·Journal of Forensic Sciences·Kaitlyn B Palmquist, Madeleine J Swortwood
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