Analysis of Fes kinase activity in myeloid cell growth and differentiation

Stem Cells
K E YatesJ C Gasson

Abstract

Fes is a nonreceptor protein tyrosine kinase that has been implicated in a variety of cytokine signal transduction pathways, as well as differentiation of myeloid cells. To address the role of Fes in these processes, we overexpressed a kinase-defective Fes protein in the factor-dependent cell-lines, TF-1 and 32D. Proliferative responses to GM-CSF and interleukin 3, and the induction of differentiation by G-CSF were not altered by expression of the kinase mutant Fes protein, indicating that Fes kinase activity is not critical for these biological events in these cell lines.

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Citations

Apr 17, 1999·Journal of Pediatric Hematology/oncology·K J KlopfensteinF B Ruymann
Feb 2, 2010·Biochemical and Biophysical Research Communications·Edwige VoissetPaulo De Sepulveda
May 8, 2002·Nature Reviews. Molecular Cell Biology·Peter Greer

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