Abstract
A genome-wide association study (GWAS) using pooled DNA samples from 386 sporadic ALS patients and 542 controls from the USA, identified genetic variation in FGGY (FLJ10986) as a risk factor, as well as 66 additional candidate SNPs. Considering the large number of hypotheses that are tested in GWAS, independent replication of associations is crucial for identifying true-positive genetic risk factors for disease. The primary aim of this study was to study the association between FGGY and sporadic ALS in large, homogeneous populations from northern Europe. Genotyping experiments were performed using Illumina Beadchips, Sequenom iPLEX assays and Taqman technology on large case-control series from The Netherlands, Belgium, Sweden and Ireland (total: 1883 sporadic ALS patients and 2063 controls). No significant association between sporadic ALS and the six previously reported associated SNPs in FGGY was observed: rs6700125 (p =0.56), rs6690993 (p =0.30), rs10493256 (p =0.68), rs6587852 (p =0.64), rs1470407 (p =0.28) and rs333662 (p =0.44). Screening of the additional candidate loci did not yield significant associations either, with the lowest p-value in joint analysis for rs7772593 (p =0.14). We concluded that common genetic variati...Continue Reading
References
Oct 1, 1994·Human Molecular Genetics·D A FiglewiczJ P Julien
Jul 22, 1993·Nature·D R Rosen
Jun 1, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·A J GrahamC H Hawkes
Mar 29, 2001·Neurology·J H VeldinkH Scheffer
Oct 5, 2001·Nature Genetics·Y YangT Siddique
Jul 9, 2003·Nature Genetics·Diether LambrechtsPeter Carmeliet
Aug 22, 2003·Genetics·Daniel FalushJonathan K Pritchard
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Mar 12, 2005·Science·Robert J KleinJosephine Hoh
Sep 28, 2005·Neurology·E F GoodallK E Morrison
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Feb 28, 2006·Nature Genetics·Matthew J GreenwayOrla Hardiman
Jul 11, 2006·Neurology·M SaeedT Siddique
Jul 25, 2006·Nature Genetics·Alkes L PriceDavid Reich
Jan 11, 2007·Archives of Neurology·Nadia A SutedjaLeonard H Van den Berg
Mar 17, 2007·Lancet Neurology·Jennifer C SchymickBryan J Traynor
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Aug 3, 2007·The New England Journal of Medicine·Travis DunckleyDietrich A Stephan
Sep 11, 2007·Lancet Neurology·Michael A van EsLeonard H van den Berg
Oct 10, 2007·Neurology·N A SutedjaL H Van den Berg
Dec 7, 2007·Human Molecular Genetics·Simon CroninOrla Hardiman
Dec 18, 2007·Nature Genetics·Michael A van EsLeonard H van den Berg
Jan 9, 2008·Neurology·Paul N Valdmanis, Guy A Rouleau
Mar 1, 2008·Science·Jemeen SreedharanChristopher E Shaw
Mar 19, 2008·Neurology·A-M WillsR H Brown
Aug 19, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·R Del BoG P Comi
Citations
Oct 27, 2011·BMC Medical Genomics·Jean-Luc C MougeotBenjamin R Brooks
Apr 4, 2012·PloS One·Lydia Coulter KweeMichael A Hauser
Apr 18, 2012·PloS One·Frank P DiekstraJan H Veldink
Aug 2, 2011·Neurobiology of Aging·Marka van BlitterswijkLeonard H van den Berg
Oct 6, 2017·Neurology·Ruben P A van EijkUNKNOWN For UKMND-LiCALS and LITALS Study Group
Oct 19, 2019·The Pharmacogenomics Journal·Ruben P A van EijkMichael A van Es
Dec 3, 2016·The Journal of Biological Chemistry·Charandeep SinghCarole L Linster
Jan 19, 2011·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Terry D Heiman-PattersonGregory Cox
Nov 8, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ji HeMatthew A Brown
May 26, 2017·Frontiers in Aging Neuroscience·Lianping XuDongsheng Fan
May 1, 2018·Frontiers in Aging Neuroscience·Lianping XuDongsheng Fan
Feb 16, 2021·Frontiers in Neuroscience·Kelly A RichStephen J Kolb