PMID: 9537583Apr 16, 1998Paper

Analysis of FHIT transcripts in cervical and endometrial cancers

International Journal of Cancer. Journal International Du Cancer
T H SuJ G Chang

Abstract

Carcinoma of the uterine cervix is a common malignancy, and many affected women, have been found to exhibit loss of heterozygosity (LOH) in the chromosome 3p region. Recent studies have localized the FHIT (fragile histidine triad) gene in this region and also demonstrated a high frequency of abnormalities of this gene in various cancers. To determine the role of the FHIT gene in cervical and uterine carcinomas, 16 cases of cervical carcinoma and 7 cases of endometrial carcinoma, as well as nearby non-cancerous tissues in these patients, were analyzed by reverse transcription of the FHIT mRNA followed by polymerase chain reaction amplification and sequencing of the products. In this study, 13 of 16 cervical cancers and 4 of 7 endometrial cancers displayed abnormal FHIT transcripts, including a lack of 2 or more exons of the FHIT gene, the insertion of several bases in the deletion junctions, and a 282 bp deletion from cDNA 171 to 452, resulting in a frameshift. Moreover, 5 of 16 matched non-cancerous tissues from the cervical cancer patients and 4 of 7 non-cancerous tissues from endometrial cancer patients also showed the presence of abnormal transcripts lacking 3 or more exons of the FHIT gene. Only 1 of 23 paired samples exhib...Continue Reading

References

Nov 22, 1991·Science·H zur Hausen
Jan 25, 1991·Cell·C J Marshall
May 1, 1991·Cancer Genetics and Cytogenetics·C SreekantaiahO Haas
Feb 1, 1990·Cancer Genetics and Cytogenetics·N B AtkinM F Fox
May 1, 1990·British Journal of Cancer·N S MurthyU K Luthra
Sep 15, 1994·International Journal of Cancer. Journal International Du Cancer·F KarlsenB Hagmar
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·G M HamptonC C Bird
Jan 1, 1993·Advances in Human Genetics·A D Goddard, E Solomon
Jan 1, 1993·CA: a Cancer Journal for Clinicians·C C BoringT Tong
Apr 5, 1996·Cell·G SozziC M Croce
Feb 1, 1997·Human Molecular Genetics·F BoldogH A Drabkin
Nov 5, 1997·International Journal of Cancer. Journal International Du Cancer·Y J ChenJ G Chang
Feb 24, 1998·British Journal of Cancer·Y J ChenJ G Chang

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Citations

Jun 21, 2008·Biochimica Et Biophysica Acta·Thomas Ming Swi Chang
Mar 13, 2014·Gynecologic Oncology·Tina Bech OlesenSusanne K Kjaer
Mar 20, 2009·Virchows Archiv : an International Journal of Pathology·Shou-Jen KuoJan-Gowth Chang
Nov 1, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Takayuki NagasawaToru Sugiyama
Dec 14, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S K Ozkara, A Corakçi
May 10, 2006·Molecular Carcinogenesis·Mu-Chin ShihJan-Gowth Chang
Mar 26, 2005·Carcinogenesis·Shou-Tung ChenJan-Gowth Chang

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