PMID: 2115456Jul 1, 1990Paper

Analysis of fibronectin, plasminogen activators and plasminogen in tear fluid as markers of corneal damage and repair

Experimental Eye Research
S BarlatiF Semeraro

Abstract

Corneal damage of various origins initiates a series of processes which lead to repair but also tend to perpetuate the damage; healing thus depends on the prevalence of repair over progression processes. The plasminogen/plasmin system has an important impact on this process, particularly by degrading the extracellular matrix components with resulting interference of the repair processes. This paper presents the immunoblotting analysis of fibronectin, tissue and urokinase-type plasminogen activators and plasminogen/plasmin in the tear fluid of control subjects and patients affected by various ocular pathologies (corneal ulcers, thermal or chemical burns, herpetic keratitis). A significant modification was noted in the protein profiles of fibronectin, tissue and urokinase-type plasminogen activators and plasminogen/plasmin in the cases of corneal ulcers and thermal or chemical burns relative to the pattern observed in the control subjects, while in cases of herpetic keratitis, only plasminogen/plasmin showed slight variations. The altered protein patterns gradually normalized during therapeutic treatment and, at remission, coincided with those of the control subjects.

References

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Citations

Oct 1, 1996·The International Journal of Biochemistry & Cell Biology·E Marchina, S Barlati
Mar 13, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Min ZhaoColin D McCaig
Apr 20, 2004·The British Journal of Ophthalmology·K ProbstA Rothova
Jul 1, 1992·American Journal of Respiratory Cell and Molecular Biology·K TakahashiM Yamamoto
Aug 28, 2010·Current Eye Research·Adrienne CsutakJózsef Tozsér
Feb 1, 1992·Annals of Medicine·T TervoK Tervo
Jan 11, 2007·Survey of Ophthalmology·K RamaeshB Dhillon
Oct 4, 2017·The Journal of Biological Chemistry·Thang Luong PhamHaydee E P Bazan
Jan 1, 1992·Acta Ophthalmologica. Supplement·T TervoA Tarkkanen
Aug 1, 1991·Acta Ophthalmologica·J Tözsér, A Berta

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