Analysis of follicle-cell functions in Drosophila: the Fs(3)Apc mutation and the development of chorionic appendages

Developmental Biology
J Szabad, G Hoffmann

Abstract

Fs(3)Apc is a dominant female-sterile mutation of Drosophila melanogaster which causes an incomplete migration of follicle cells between the oocyte and the nurse cells. This leads to leakage of anterior egg cytoplasm followed by degeneration of the egg primordium or deposition of flaccid eggs with reduced anterior egg coverings including the dorsal appendages. Analysis of ovarian and germ-line chimeras revealed that the focus of the Apc phenotype is located in the ovarian soma. Apc+ clones, induced by mitotic recombination, lead to the formation of "exceptional" eggs with (often partial) rescue of the mutant phenotype. Analysis of Apc+ mosaics shows that the Apc mutant phenotype depends on the genotype of the anterior follicle cells. The patterns of apparent Apc+ clones suggest that there is no lineage restriction between the follicle cells that form the anterior egg coverings and those that form the dorsal appendages at the follicle envelope stage.

References

Jul 1, 1986·Genetics·N PerrimonA P Mahowald
Jan 1, 1988·Molecular & General Genetics : MGG·J SzabadM B Schröder
Dec 18, 1987·Science·C Nüsslein-VolhardR Lehmann
Mar 1, 1978·Wilhelm Roux's Archives of Developmental Biology·Eric WieschausWalter Gehring
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Jul 1, 1986·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Trudi Schüpbach, Eric Wieschaus

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Citations

May 1, 1990·Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists·B KnibiehlerY Le Parco

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