Analysis of four 5-nitroimidazoles and their corresponding hydroxylated metabolites in egg, processed egg, and chicken meat by isotope dilution liquid chromatography tandem mass spectrometry

Journal of Agricultural and Food Chemistry
Pascal MottierPhilippe A Guy

Abstract

An isotope dilution liquid chromatography-electrospray ionization-tandem mass spectrometry method is presented for the simultaneous analysis of several 5-nitroimidazole-based veterinary drugs, which are dimetridazole (DMZ), ronidazole (RNZ), metronidazole (MNZ), ipronidazole (IPZ), and their hydroxylated metabolites (DMZOH, MNZOH, and IPZOH), in egg (fresh egg, whole egg powder, and egg yolk powder) and chicken meat. Data acquisition was achieved by applying multiple reaction monitoring, and quantitation was performed by means of five deuterated internal standards (ISs), namely, DMZ-d3, RNZ-d3, IPZ-d3, DMZOH-d3, and IPZOH-d3, whereas MNZ and MNZOH were quantitated using DMZOH-d3. At the lowest fortification levels (i.e., 0.5 microg/kg for fresh egg and chicken meat and 1.0 microg/kg for other egg-based matrices) and for compounds having their own corresponding deuterated analogue used as an IS, acceptable performance data were obtained (corrected recoveries, 88-111%; decision limits, 0.07-0.36 microg/kg; detection capabilities, 0.11-0.60 microg/kg; and within-lab precision, < or = 15%). The method failed to give acceptable quantitative results for MNZ and MNZOH due to the unavailability of the corresponding deuterated ISs. Neve...Continue Reading

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Citations

Mar 22, 2012·Analytical and Bioanalytical Chemistry·Maykel Hernández-MesaAna M García-Campaña
Jul 3, 2010·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·M CronlyL Regan
Apr 10, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Hana Zelníčková, Martina Rejtharová
Mar 9, 2011·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Miho SakamotoToshihiro Nagayama
Apr 27, 2010·Analytica Chimica Acta·Cristina Mahugo-SantanaJosé Juan Santana-Rodríguez
Sep 29, 2009·Journal of Chromatography. a·Brian KinsellaMartin Danaher
Apr 7, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Mark CronlyLiam Regan
May 6, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Anna GadajMartin Danaher
Nov 6, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Anna GadajMartin Danaher
Dec 1, 2006·Journal of Mass Spectrometry : JMS
Apr 3, 2020·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Juliana Aparecida DinizAstréa Filomena Souza Silva
Sep 20, 2019·Journal of Agricultural and Food Chemistry·Qianqian WangZhi Wang

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