PMID: 3768937Jul 1, 1986Paper

Analysis of free growth and post-treatment regrowth of C3H mammary carcinoma in individual mice

Cell and Tissue Kinetics
R DemicheliG Savi

Abstract

Free growth and post-Doxorubicin treatment regrowth of the C3H mammary carcinoma were analysed in individual mice. In both cases, the Gompertzian function provided a better fit than the exponential function, and the difference was statistically significant (P less than 0.001, chi 2 test). No comprehensive Gompertzian function was found, and each individual tumour growth or regrowth was described by a specific curve. Nevertheless, although both individually measured alpha 0 and beta, Gompertzian parameters varied from one animal to another, in both free-growing and post-treatment regrowing tumours a strong linear correlation between alpha 0 and beta was found. A parallelism test was performed to verify if there exists any treatment-induced alteration. The two regression lines appeared to be identical, however.

References

Mar 1, 1978·Cell and Tissue Kinetics·G F Brunton, T E Wheldon
Jul 1, 1972·The Journal of Clinical Investigation·P W Sullivan, S E Salmon
Aug 1, 1981·European Journal of Cancer & Clinical Oncology·R E LenhardM D Abeloff
Dec 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R Demicheli
Jul 1, 1980·Cell and Tissue Kinetics·G G Steel
Sep 1, 1964·British Journal of Cancer·A K LAIRD

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Citations

Jan 8, 1999·Breast Cancer Research and Treatment·R DemicheliG Bonadonna
Nov 30, 2007·Free Radical Biology & Medicine·Sabrina DoblasRheal A Towner

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