PMID: 9189270Jun 1, 1997Paper

Analysis of galanin and the galanin antagonist M40 on delayed non-matching-to-position performance in rats lesioned with the cholinergic immunotoxin 192 IgG-saporin

Behavioral Neuroscience
M P McDonaldJ N Crawley

Abstract

Galanin is a 29-amino-acid neuropeptide that is overexpressed in Alzheimer's disease (AD) and impairs performance on rodent learning and memory tasks. M40, a peptidergic galanin receptor ligand, blocks galanin-induced impairments on delayed non-matching-to-position (DNMTP). The present experiments used the 192IgG-saporin lesion model of AD to evaluate the actions of galanin and M40 on DNMTP when cholinergic transmission was reduced. Hippocampal choline acetyltransferase levels were correlated with DNMTP choice accuracy in lesioned rats. Intracerebroventricular (icv) galanin reduced choice accuracy in both the lesioned and sham groups. M40 alone, either icv or intrahippocampal, did not affect choice accuracy in either group. These results suggest that excess galanin can produce further deficits in DNMTP performance in a lesion model of AD, but blocking endogenous galanin is not sufficient alone to improve performance in lesioned rats.

Citations

Jan 5, 2002·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·L M Savage
May 27, 2008·Cellular and Molecular Life Sciences : CMLS·J N Crawley
Sep 22, 1995·Regulatory Peptides·J N Crawley
Mar 27, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·C C Wrenn, J N Crawley
Nov 24, 2001·Neuroscience·C C Wrenn, R G Wiley
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C C Wrenn, R G Wiley
May 10, 2003·Neurobiology of Learning and Memory·Jefferson W KinneyJacqueline N Crawley
Feb 3, 1999·Annals of the New York Academy of Sciences·M P McDonaldJ N Crawley
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·G O'MearaD Wynick
Jul 6, 2004·Physiology & Behavior·Rebecca L Corwin, Ariel Buda-Levin
Feb 9, 2008·Neurobiology of Aging·Alexandra BernardoMichael P McDonald
Apr 7, 2005·Behavioral and Cognitive Neuroscience Reviews·John K Robinson
Feb 3, 1999·Annals of the New York Academy of Sciences·D WynickV Pachnis
Nov 25, 2004·Endocrine Reviews·Roy G SmithYuxiang Sun

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