Abstract
We investigated gender difference in the effects of chronic exposure to human growth hormone (hGH) on cardiac risk biomarkers using transgenic mice with non-pulsatile circulating hGH. Blood plasma was obtained from transgenic and control mice at 8, 12, and 16 weeks of age, and was used for the measurement of hGH and the following cardiac risk biomarkers: total cholesterol (CHO), triglyceride (TG), HDL cholesterol (HDL), LDL cholesterol (LDL), non esterified free fatty acids (NEFA), and lipid peroxides (LPO). The hearts and the livers of transgenic mice were weighed and histopathologically examined, and the results were compared with those of control mice. Transgenic males exhibited higher levels of LDL at 8 and 12 weeks of age and higher levels of LPO at every week of age examined, as compared to those of the control males, while transgenic females exhibited somewhat lower levels of LDL and LPO from 8 to 16 weeks of age, as compared to the control females. The relative heart weight in males increased with aging and was significantly higher in the 16-week-old transgenic males compared to those of the control mice. The present results demonstrate that transgenic males had cardiac risk potential caused by chronic-exposure to hGH a...Continue Reading
References
Dec 15, 1991·Gene·H NiwaJ Miyazaki
Dec 1, 1991·The Journal of Endocrinology·J N MacLeodB H Shapiro
Aug 4, 1990·Lancet·T Rosén, B A Bengtsson
Jan 1, 1990·Annals of the New York Academy of Sciences·F M Sacks, B W Walsh
Jan 1, 1988·Free Radical Biology & Medicine·B Hennig, C K Chow
Jan 1, 1988·Acta Medica Scandinavica·B A BengtssonB Sjögren
Mar 1, 1972·Circulation Research·H Wolinsky
Jan 1, 1983·Journal of Biochemistry·T IgarashiH Kitagawa
Jul 1, 1980·Metabolism: Clinical and Experimental·T MuraseS Yoshida
Jun 1, 1994·The Journal of Clinical Endocrinology and Metabolism·I HarantM Garrigues
Mar 28, 1996·The New England Journal of Medicine·S FazioL Saccà
Apr 1, 1997·Biology of Reproduction·A IkedaM Takahashi
Aug 1, 1997·Journal of Neuroendocrinology·F SasakiC Tachi
Jun 30, 1998·Current Opinion in Lipidology·S Santamarina-FojoM Amar
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·K OkaT Masaki
Jan 27, 2000·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J TakahashiS Fujita
Oct 14, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·S ToshimaR Nagai
Apr 3, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S J Hauck, A Bartke
Jun 20, 2001·Trends in Cardiovascular Medicine·N Kume, T Kita
Nov 10, 2001·American Journal of Physiology. Endocrinology and Metabolism·F FrickJ Oscarsson
Jan 5, 2002·American Journal of Clinical Dermatology·M Rademaker
Nov 1, 2002·The Journal of Experimental Zoology·Jun KuboHideaki Tojo
May 9, 2003·American Journal of Physiology. Endocrinology and Metabolism·Bob OlssonJan Törnell