Analysis of genetic expression in the soft palate of patients with obstructive sleep apnea

Acta Oto-laryngologica
Chang Myeon SongJeong-Whun Kim

Abstract

Genetic dysregulation may be associated with development of obstructive sleep apnea (OSA). Genetic expression was investigated in the soft palate of patients with OSA to evaluate the biomolecular characteristics of the tissue where airway obstruction actually occurs. Soft palate mucosa was obtained during uvulopalatal flap surgery. Three patients with apnea/hypopnea index (AHI) >30/h and three simple snoring patients with AHI < 5/h were enrolled. After total RNA was extracted and amplified, gene expression levels were determined by microarray analysis, and relative signal intensities for each gene were evaluated. Of the 45,034 genes analyzed, 137 were up-regulated in OSA patients compared with simple snorers and 95 were down-regulated. Gene network analysis showed that genes related to RNA interference and transcription were most commonly involved in the functional pathophysiology of OSA. In particular, genes encoding proliferating cell nuclear antigen and proteasome 26S subunit ATPase 6 were functionally connected with other genes.

References

Oct 23, 2002·Journal of Applied Physiology·Eijiro OhgaYasuyoshi Ouchi
May 21, 2004·American Journal of Respiratory and Critical Care Medicine·John H BoydR John Kimoff
Feb 24, 2006·Sleep & Breathing = Schlaf & Atmung·Aung K HtooShu Fang Liu
Mar 1, 2006·The Journal of Laboratory and Clinical Medicine·Choong-Chin LiewAdam A Dempsey
Mar 10, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Patrick F SullivanCharles M Perou
Apr 21, 2006·Archives of Medical Research·Carlos Zamarrón-SanzAlberto Riveiro-Riveiro
Oct 6, 2006·Journal of Molecular and Cellular Cardiology·Luisa NanniGerolamo Lanfranchi
Nov 30, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Kenji Izuhara, Hirohisa Saito
Dec 7, 2006·Respiration; International Review of Thoracic Diseases·Ahmet UrsavaşR Oktay Gözü
May 22, 2007·Antioxidants & Redox Signaling·Michal S HoffmannVirend K Somers
Mar 3, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Mei-Yu LeeKun-Ming Wu
May 6, 2009·Sleep & Breathing = Schlaf & Atmung·Nabil Al LawatiNajib Ayas
Jan 23, 2010·American Journal of Respiratory and Critical Care Medicine·Abdelnaby KhalyfaDavid Gozal
Jun 15, 2010·Trends in Biochemical Sciences·Nerea Gallastegui, Michael Groll
Oct 27, 2010·The Journal of Experimental Medicine·Véronique Witko-SarsatMarco A Cassatella

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