Analysis of Genomic Alteration in Primary Central Nervous System Lymphoma and the Expression of Some Related Genes

Neoplasia : an International Journal for Oncology Research
Yangying ZhouMeizuo Zhong

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare and special type of non-Hodgkin lymphoma. The treatment of PCNSL is comprehensive, combining surgery, radiotherapy, and chemotherapy. However, the outcome is poor because of its high invasiveness and rate of recurrence. We analyzed 22 cases of PCNSL using next-generation sequencing (NGS) to detect 64 candidate genes. We used immunohistochemical methods to analyze gene expression in 57 PCNSL samples. NGS showed that recurrent mutations in KMT2D and CD79B, components of the NF-κB pathway, accounted for 65% of total mutations in PCNSL samples. The most frequent mutated gene was PIM1 (77.27%, 17/22), followed by MYD88 (63.64%, 14/22), CD79B (69.09%, 13/22), and KMT2D (50.00%, 11/22). Mutations of the CD79B gene were associated with an inferior progression-free survival (PFS), and GNA13 gene mutations were associated with a shorter PFS and overall survival (OS) in PCNSL patients (P < .05). PIM1 and MYD88 were highly expressed in PCNSL patients and were related to their OS time. MYD88 overexpression might be an independent and poor prognostic predictor of OS time. In summary, we identified highly recurrent genetic lesions in CD79B and KMT2D, components of the NF-κB pathway, in...Continue Reading

Citations

Dec 31, 2019·Journal of Neuropathology and Experimental Neurology·Csaba BödörLilla Reiniger
Nov 19, 2019·Pathology·Narittee SukswaiL Jeffrey Medeiros
Dec 15, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Adam R DavisAdam Bagg
Feb 14, 2021·Cancer Treatment and Research Communications·Mohamad BarakatHaifaa Abdulhaq
Jun 3, 2021·Cancers·Alexander Baraniskin, Roland Schroers
Jul 30, 2021·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Sang Eun YoonSeok Jin Kim

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Methods Mentioned

BETA
biopsy
imaging techniques
acetylation

Clinical Trials Mentioned

NCT02092909
NCT00848601
NCT01854606

Software Mentioned

GraphPad Prism
R
ANNOVARt37
DAVID Bioinformatics Resources
GATK Realigner Target Creator
InNels
Burrows Wheeler Aligner
GeneCards
FastQC
Indel Realigner

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