Analysis of Granulomatous Lymphocytic Interstitial Lung Disease Using Two Scoring Systems for Computed Tomography Scans-A Retrospective Cohort Study.

Frontiers in Immunology
Jennifer J MeerburgHarm A W M Tiddens

Abstract

Granulomatous lymphocytic interstitial lung disease (GLILD) is present in about 20% of patients with common variable immunodeficiency disorders (CVID). GLILD is characterized by nodules, reticulation, and ground-glass opacities on CT scans. To date, large cohort studies that include sensitive CT outcome measures are lacking, and severity of structural lung disease remains unknown. The aim of this study was to introduce and compare two scoring methods to phenotype CT scans of GLILD patients. Patients were enrolled in the "Study of Interstitial Lung Disease in Primary Antibody Deficiency" (STILPAD) international cohort. Inclusion criteria were diagnosis of both CVID and GLILD, as defined by the treating immunologist and radiologist. Retrospectively collected CT scans were scored systematically with the Baumann and Hartmann methods. In total, 356 CT scans from 138 patients were included. Cross-sectionally, 95% of patients met a radiological definition of GLILD using both methods. Bronchiectasis was present in 82% of patients. Inter-observer reproducibility (intraclass correlation coefficients) of GLILD and airway disease were 0.84 and 0.69 for the Hartmann method and 0.74 and 0.42 for the Baumann method. In both the Hartmann and B...Continue Reading

References

Jul 22, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·C Cunningham-Rundles, C Bodian
Dec 22, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M E ConleyA Etzioni
Sep 27, 2002·QJM : Monthly Journal of the Association of Physicians·K M ThickettD E Stableforth
Aug 19, 2004·The Journal of Allergy and Clinical Immunology·Christopher A BatesJohn M Routes
Sep 7, 2006·Journal of Computer Assisted Tomography·Nobuyuki TanakaDavid A Lynch
Jan 16, 2008·Radiology·David M HansellJacques Remy
Feb 3, 2009·Respiratory Medicine·Stina GregersenBjørn Johansen
Nov 11, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Joon H Park, Arnold I Levinson
Nov 17, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Catharina M L TouwJoris M van Montfrans
Jun 24, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Stina GregersenStig S Frøland
Aug 3, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jordan S OrangeMahlon M Wilkes
Feb 23, 2011·Allergologia et immunopathologia·Beatriz T Costa-CarvalhoDirceu Solé
Jul 14, 2011·JAMA : the Journal of the American Medical Association·Claire E WainwrightUNKNOWN ACFBAL Study Investigators
Dec 20, 2011·Blood·Elena S ResnickCharlotte Cunningham-Rundles
Jul 24, 2012·The Journal of Allergy and Clinical Immunology·Helen ChapelEric Oksenhendler
Aug 21, 2012·The European Respiratory Journal·Diane BouvryUNKNOWN Groupe Sarcoïdose Francophone
Jul 25, 2013·Current Opinion in Pulmonary Medicine·Antje PrasseKlaus Warnatz
Aug 24, 2013·Journal of Thoracic Imaging·Brian J BartholmaiRichard A Robb
Mar 4, 2014·The Journal of Allergy and Clinical Immunology·Benjamin GathmannUNKNOWN European Society for Immunodeficiencies Registry Working Party
Jun 2, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Paul J MaglioneCharlotte Cunningham-Rundles
Mar 11, 2015·American Journal of Respiratory and Critical Care Medicine·Tim RosenowUNKNOWN Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF)
Sep 16, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Paul J MaglioneCharlotte Cunningham-Rundles
Nov 14, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Francisco A BonillaKlaus Warnatz
Nov 21, 2015·Thorax·Simon L F WalshUNKNOWN UIP Observer Consort
Apr 12, 2016·Annals of the American Thoracic Society·Amar ManninaEvans R Fernández Pérez
Apr 15, 2016·The European Respiratory Journal·Wieying KuoUNKNOWN ECFS-CTN/SCIFI CF study group
Jun 9, 2016·Pediatric Pulmonology·Elizabeth SalamonHarm A W M Tiddens
Jun 23, 2016·Journal of Chiropractic Medicine·Terry K Koo, Mae Y Li
Jan 4, 2017·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Rhonda SzczesniakHarm A W M Tiddens
Mar 4, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Stella HartonoAvni Y Joshi
Dec 14, 2018·Journal of Clinical Immunology·Katharina SchützUNKNOWN Chest CT in Antibody Deficiency Group
Mar 8, 2019·JCI Insight·Paul J MaglioneCharlotte Cunningham-Rundles

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

R
SPSS

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