Analysis of heterogeneous gallstones using laser-induced breakdown spectroscopy (LIBS) and wavelength dispersive X-ray fluorescence (WD-XRF)

Lasers in Medical Science
Brij Bir S JaswalVivek K Singh

Abstract

Laser-induced breakdown spectroscopy (LIBS) is an emerging analytical technique with numerous advantages such as rapidity, multi-elemental analysis, no specific sample preparation requirements, non-destructiveness, and versatility. It has been proven to be a robust elemental analysis tool attracting interest because of being applied to a wide range of materials including biomaterials. In this paper, we have performed spectroscopic studies on gallstones which are heterogeneous in nature using LIBS and wavelength dispersive X-ray fluorescence (WD-XRF) techniques. It has been observed that the presence and relative concentrations of trace elements in different kind of gallstones (cholesterol and pigment gallstones) can easily be determined using LIBS technique. From the experiments carried out on gallstones for trace elemental mapping and detection, it was found that LIBS is a robust tool for such biomedical applications. The stone samples studied in the present paper were classified using the Fourier transform infrared (FTIR) spectroscopy. WD-XRF spectroscopy has been applied for the qualitative and quantitative analysis of major and trace elements present in the gallstone which was compared with the LIBS data. The results obtain...Continue Reading

References

Sep 30, 2005·Lasers in Medical Science·Xiao FangSyed Iqbal
Dec 24, 2008·Lasers in Medical Science·V K SinghP K Jindal
Jan 6, 2009·Applied Optics·Vivek K SinghJagdish P Singh
Feb 15, 2011·Lasers in Medical Science·Ashok Kumar PathakG D Baruah
May 3, 2011·Lasers in Medical Science·Vivek Kumar Singh, Awadhesh Kumar Rai

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Citations

Dec 19, 2016·The Journal of Veterinary Medical Science·Shinya MizutaniKiyokazu Naganobu
Jan 25, 2020·Analytical Biochemistry·Anca PeterFlaviu Gheorghe Pop

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