Analysis of high-perimeter planar electrodes for efficient neural stimulation.

Frontiers in Neuroengineering
Xuefeng F Wei, Warren M Grill

Abstract

Planar electrodes are used in epidural spinal cord stimulation and epidural cortical stimulation. Electrode geometry is one approach to increase the efficiency of neural stimulation and reduce the power required to produce the level of activation required for clinical efficacy. Our hypothesis was that electrode geometries that increased the variation of current density on the electrode surface would increase stimulation efficiency. High-perimeter planar disk electrodes were designed with sinuous (serpentine) variation in the perimeter. Prototypes were fabricated that had equal surface areas but perimeters equal to two, three or four times the perimeter of a circular disk electrode. The interface impedance of high-perimeter prototype electrodes measured in vitro did not differ significantly from that of the circular electrode over a wide range of frequencies. Finite element models indicated that the variation of current density was significantly higher on the surface of the high-perimeter electrodes. We quantified activation of 100 model axons randomly positioned around the electrodes. Input-output curves of the percentage of axons activated as a function of stimulation intensity indicated that the stimulation efficiency was dep...Continue Reading

Citations

Jun 28, 2014·Frontiers in Neuroengineering·Sharanya Arcot DesaiRobert E Gross
Jun 3, 2016·Computers in Biology and Medicine·Wenyan JiaMingui Sun
Jul 15, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Takashi D Y Kozai, Alberto L Vazquez
Jul 17, 2014·Journal of Neural Engineering·Bryan Howell, Warren M Grill
Nov 26, 2019·Advanced Healthcare Materials·Annarita Cutrone, Silvestro Micera
Dec 23, 2016·Frontiers in Neuroscience·Matthew R MacEwanDaniel W Moran
May 29, 2018·Advanced Functional Materials·Steven M WellmanTakashi D Y Kozai
Jan 20, 2019·Journal of Neuroengineering and Rehabilitation·Clara GünterMax Ortiz-Catalan
Apr 13, 2021·Journal of Medical Engineering & Technology·Léo Pio-LopezDamien Depannemaecker

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