Analysis of highly phosphorylated inositols in avian and crocodilian erythrocytes

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
José Luís VillarMiquel Riera-Codina

Abstract

Both morphological and paleontological characteristics support the hypothesis of a monophyletic origin of crocodilian and avian groups. However, while the erythrocytes of all birds studied to date are reported to contain high levels of inositol pentakisphosphate (InsP(5)), which acts as an allosteric effector of hemoglobin, this molecule has not been reported in crocodilian erythrocytes. In this study we compare the highly phosphorylated inositols in crocodilian and avian erythrocytes using a particularly sensitive analytical procedure. Our aim was to obtain new data which might provide further evidence for the monophyletic origin, or otherwise, of crocodiles and birds. We studied three avian and three crocodilian species. The erythrocytes of the three bird species contained low levels of inositol-3,4,5,6-tetrakisphosphate and inositol-1,3,4,6-tetrakisphosphate, thought to be precursors of Ins(1,3,4,5,6)P(5). The crocodilian erythrocytes studied contained Ins(1,3,4,5,6)P(5) and InsP(6) in higher concentrations than those found in mammal erythrocytes and in other more active cells such as macrophages. Our data provide further evidence of the similarity between crocodilian and avian groups and agree with the hypothesis that both ...Continue Reading

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Citations

May 6, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Nicolás VeigaCarlos Kremer
Jun 1, 2014·Environmental Science and Pollution Research International·Wen-Ling ChenChia-Yang Chen
Dec 18, 2015·Dose-response : a Publication of International Hormesis Society·Jone CorralesBryan W Brooks
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Robert H Michell
Dec 9, 2008·Bioscience, Biotechnology, and Biochemistry·Osamu HayashiKiyoshi Satoh
Aug 4, 2007·Critical Reviews in Toxicology·Jeong-Hun KangYoshiki Katayama
May 31, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roy E WeberThomas A Gorr
May 10, 2015·Environmental Science and Pollution Research International·Viganò LuigiRoscioli Claudio
Dec 4, 2013·Environmental Science & Technology·Alexandre R R PéryRémy Beaudouin
Mar 22, 2014·Chemical Research in Toxicology·Sergio ManzettiDavid van der Spoel

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