Analysis of HLA genes in families with autoimmune diabetes and thyroiditis

Human Immunology
Lara LevinYaron Tomer

Abstract

Type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) are the most common autoimmune endocrine disorders. The similar pathogenesis of T1D and AITD and their tendency to occur together suggest that their etiology may involve common genetic factors. We hypothesized that the human leukocyte antigen (HLA) locus may contribute in part to the joint susceptibility to T1D and AITD. We therefore analyzed a data set of 40 multiplex families in which T1D and AITD clustered ("T1D-AITD families") for linkage and association with the HLA class II locus. We found evidence for linkage of the HLA region to T1D (maximum logarithm of odds score [MLS] = 7.3), to Hashimoto thyroiditis (HT) (MLS = 1.5), and to both (MLS = 3.8). Transmission disequilibrium test analysis revealed significant association of both T1D and AITD with HLA-DR3; however, only T1D was associated with HLA-DR4. We concluded that the finding of evidence for linkage of HLA with HT is in contrast to the strong evidence against linkage found in previous studies of AITD-only families; therefore, it is possible that the AITD phenotype seen in T1D families has a different genetic etiology than the AITD phenotype in AITD-only families; that HLA-DR3 was the major HLA allele contrib...Continue Reading

References

Oct 1, 1978·Annals of Human Genetics·J Ott
Jan 1, 1989·Genetic Epidemiology·H PayamiG Thomson
Nov 1, 1973·The Journal of Clinical Endocrinology and Metabolism·H H BodeA P Forbes
Jan 1, 1981·Endocrine Reviews·N R Farid, J C Bear
Jan 1, 1982·The Journal of Pediatrics·G M BrightW L Clarke
Sep 1, 1981·The Journal of Pediatrics·W J RileyA L Rosenbloom
Apr 1, 1993·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·P WestmanS Koskimies
Dec 1, 1994·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·P L Balducci-SilanoR Zaro
Apr 16, 1998·American Journal of Human Genetics·R S Spielman, W J Ewens
Jun 26, 1998·Clinical Endocrinology·T H BrixL Hegedüs
Aug 27, 1998·American Journal of Human Genetics·D A GreenbergS E Hodge
Jun 17, 1999·Human Molecular Genetics·B VaidyaS H Pearce
Oct 12, 1999·Diabetes, Nutrition & Metabolism·M B RoldánR Barrio
Apr 14, 2000·American Journal of Human Genetics·B VaidyaS H Pearce
May 10, 2000·Nature Genetics·D F GudbjartssonA Kong
Mar 16, 2001·Human Immunology·S G Marsh, UNKNOWN WHO Nomenclature Committee for factors of the HLA system
Mar 16, 2001·Human Immunology·S G Marsh, UNKNOWN WHO Nomenclature Committee for factors of the HLA system
Apr 4, 2001·Tissue Antigens·S G MarshP I Terasaki
Jan 16, 2002·American Journal of Human Genetics·C M LindgrenE S Lander
Jul 26, 2002·Genes and Immunity·F Pociot, M F McDermott
Dec 20, 2002·Thyroid : Official Journal of the American Thyroid Association·Richard C Jenkins, Anthony P Weetman

❮ Previous
Next ❯

Citations

Feb 15, 2008·Cancer Immunology, Immunotherapy : CII·Wei-Zen WeiYi-chi M Kong
Sep 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Francesca MenconiYaron Tomer
Sep 30, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Rodney R Dietert, Janice M Dietert
Jul 25, 2008·Thyroid : Official Journal of the American Thyroid Association·James C BartonUNKNOWN Hemochromatosis and Iron Overload Screening Study Research Investigators
Feb 5, 2009·Thyroid : Official Journal of the American Thyroid Association·Yaron Tomer, Francesca Menconi
Jun 29, 2010·Thyroid : Official Journal of the American Thyroid Association·Manuela Dittmar, George J Kahaly
Mar 15, 2005·Journal of Autoimmune Diseases·Dimitry A Chistiakov
Jun 2, 2005·The Journal of Clinical Endocrinology and Metabolism·Brian GoldenYaron Tomer
Jan 15, 2009·The Journal of Clinical Endocrinology and Metabolism·Maria Justina B VillanoYaron Tomer
Jul 26, 2011·Journal of Thyroid Research·Mirella HageSami T Azar
Jan 13, 2006·International Review of Psychiatry·Carlos A PardoAndrew W Zimmerman
Oct 17, 2015·Expert Review of Clinical Immunology·Antonella DiamantiMattia Locatelli
Nov 13, 2013·Expert Review of Clinical Immunology·Antonella DiamantiMattia Locatelli
Nov 20, 2012·La Presse médicale·George J Kahaly
May 11, 2010·Journal of Neuroimmunology·Gehan A Mostafa, Abeer A Shehab
Feb 26, 2010·The Journal of Investigative Dermatology·Jonathan D MozenaLarry Borish
Nov 1, 2006·Pediatric Neurology·Li-Ching LeeAndrew W Zimmerman
May 6, 2015·Journal of Autoimmunity·Yaron TomerUNKNOWN SEARCH for Diabetes in Youth Study
Nov 1, 2012·Journal of Neuroimmunology·Gehan A MostafaLaila Y Al-Ayadhi
Dec 14, 2017·European Thyroid Journal·Berglind JonsdottirUNKNOWN DiPiS Study Group
Jan 17, 2019·Endocrine Reviews·Bernadette BiondiR Paul Robertson
Nov 2, 2019·The Journal of Clinical Endocrinology and Metabolism·Lara FrommerGeorge J Kahaly
Jan 31, 2021·Thyroid : Official Journal of the American Thyroid Association·Hyun Jung KimHyeong Sik Ahn
Mar 30, 2021·Frontiers in Endocrinology·Lara Frommer, George J Kahaly
Mar 18, 2021·Annals of African Medicine·Sara DerrouSomaya Safi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.