Analysis of human T cell response to two Plasmodium falciparum merozoite surface antigens.

European Journal of Immunology
C M RzepczykM Honeyman

Abstract

Eight novel human T cell epitopes were identified within the two major merozoite surface antigens (MSA1 and MSA2) of Plasmodium falciparum using synthetic peptides. All except one of the peptides conformed structurally to an amphipathic alpha helix and three out of the four MSA1 peptides also contained sequences containing the Rothbard motif. Peptide MSA2/2, which fitted none of these criteria, was recognized by our donors to a similar degree as the other peptides. This peptide also contains a B cell epitope. Proliferative responses were obtained in both immune and nonimmune donors, however, the number of responses in the immune donor group was significantly higher. There was no correlation between the level of proliferation and antibody titers to these antigens. No peptides were preferentially recognized in association with specific HLA class II antigens.

References

Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C DeLisi, J A Berzofsky
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M F GoodL H Miller
Jan 15, 1988·Molecular and Biochemical Parasitology·M G PetersonD J Kemp
Apr 1, 1988·European Journal of Immunology·F SinigagliaJ R Pink
Jan 1, 1989·Molecular and Biochemical Parasitology·J T ClarkJ S McBride
May 20, 1987·Journal of Molecular Biology·K TanabeJ G Scaife
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J A SmytheR F Anders
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·W A SiddiquiS C Kan
Apr 1, 1985·Human Immunology·G CraneH Bashir
Aug 1, 1984·The Journal of Experimental Medicine·L H PerrinR Richle

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Citations

Apr 1, 1995·Molecular and Biochemical Parasitology·M K Hughes, A L Hughes
Feb 1, 1997·International Journal for Parasitology·C M RzepczykM Whitby
Mar 22, 2000·The Journal of Peptide Research : Official Journal of the American Peptide Society·M OcampoM E Patarroyo
Apr 3, 2002·The Journal of Experimental Medicine·Huji XuMichael F Good
Jan 1, 1992·Scandinavian Journal of Immunology. Supplement·I A QuakyiM F Good
Feb 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L HviidT G Theander
Jan 1, 1994·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A B Cruz CubasL Monjour
Nov 13, 2004·Clinical and Diagnostic Laboratory Immunology·Marcelo U FerreiraGerhard Wunderlich
Aug 1, 1990·European Journal of Immunology·P D SimitsekL H Perrin
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francis M NdunguJean Langhorne
Apr 18, 1998·Biochimica Et Biophysica Acta·R Ramasamy

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