Analysis of hydrazine in smokeless tobacco products by gas chromatography-mass spectrometry

Chemistry Central Journal
Kevin G McAdamBrad Rodu

Abstract

Due to the lower health risks associated with the use of certain categories of smokeless tobacco products (STPs) such as Swedish snus, there is interest in the comparative levels of toxic chemical constituents in different types of STPs. A method has been developed and validated for the analysis of hydrazine in STPs. Seventy four commercial STPs from the US and Sweden, representing 80-90% of the 2010 market share for all the major STP categories in these two countries, as well as three reference STPs, were analysed for hydrazine. Aqueous extracts of the STPs were treated with excess pentafluorobenzaldehyde (PFB), which reacted with hydrazine in solution to form decafluorobenzaldehyde azine (DFBA). DFBA was partitioned into hexane and then quantified by gas chromatography-mass spectrometry (GC-MS). The method was validated using five different types of STP, was linear in the range 8-170 ng/mL, and had limits of quantification (LOQ) from 26-53 ng of hydrazine per g of STP (as sold). The method was applied to the analysis of 74 contemporary STPs commercially available in the United States and Sweden, none of which were found to contain hydrazine above the LOQ or LOD. Trace levels of compounds showing chromatographic and mass spect...Continue Reading

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Sep 10, 2013·Chemistry Central Journal·Kevin G McAdamBrad Rodu

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Citations

Oct 17, 2015·Chemistry Central Journal·Kevin McAdamBrad Rodu
Dec 20, 2017·Chemistry Central Journal·K McAdamB Rodu
Nov 12, 2019·Journal of Chromatographic Science·Mehran SharifiPeter Joza
May 14, 2020·Critical Reviews in Analytical Chemistry·Félix Zapata, Carmen García-Ruiz
May 11, 2019·Scientific Reports·Jasmine KaurHarpreet Singh
Dec 21, 2018·Chemistry Central Journal·Kevin McAdamBrad Rodu
Aug 12, 2021·Chemical Research in Toxicology·Peter S Spencer, Glen E Kisby

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