Analysis of hydroxylated polybrominated diphenyl ether metabolites by liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
Sara J LuptonDiana S Aga

Abstract

Hydroxylated polybrominated diphenyl ether (OH-PBDEs) metabolites have the potential to cause endocrine disruption as well as other health effects. Currently, gas chromatography/mass spectrometry (GC/MS) after derivatization is used for the analysis of OH-PBDEs. However, there is a need for the direct analysis of OH-PBDEs at relatively low concentrations in environmental and biological samples. Liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry (LC/APCI-MS/MS) was evaluated for the analysis of nine OH-PBDEs, ranging from tri- to hexabrominated. Separation of the nine isomeric metabolites was achieved with reversed-phase liquid chromatography, followed by detection by APCI-MS in negative mode. Notably, a significant decrease in ionization was observed in 6-hydroxyl-substituted PBDE metabolites in the presence of an ortho-substituted bromine, relative to the other hydroxylated metabolites. This is probably due to the formation of dioxins in the source as a result of the high-temperature conditions, which prevented ionization by hydrogen abstraction. The MS/MS experiments also provided evidence of the neutral losses of HBr and Br(2), indicating the possible use of neutral loss scanning and...Continue Reading

References

Jun 28, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·I A MeertsA Brouwer
Dec 13, 2006·Journal of Toxicology and Environmental Health. Part a·Arnold SchecterRobin Rosen
Apr 3, 2007·Environmental Science & Technology·Nerissa WuThomas F Webster
Jan 11, 2008·Molecular Nutrition & Food Research·Britta FängströmAke Bergman
Jan 24, 2009·Environmental Health Perspectives·Xinghua QiuRonald A Hites

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Citations

Jun 16, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Claudio A ErraticoStelvio M Bandiera
Dec 20, 2012·Environmental Health Perspectives·Maria Luisa FeoJames R Olson
Jun 29, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Claudio A ErraticoStelvio M Bandiera
Sep 6, 2011·International Journal of Hygiene and Environmental Health·Pierre Le CannBarbara Le Bot
Apr 12, 2011·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Yongquan LaiZongwei Cai
Sep 20, 2016·International Journal for Ion Mobility Spectrometry : Official Publication of the International Society for Ion Mobility Spectrometry·Kendra J AdamsFrancisco Fernandez-Lima
Apr 10, 2012·Talanta·Sylwia KrólJacek Namieśnik
Jun 7, 2016·The Science of the Total Environment·Silviu-Laurentiu BadeaEthel Eljarrat
Jun 30, 2012·Analytical Chemistry·Payam AqaiMichel W F Nielen
Dec 8, 2011·Analytical Chemistry·Susan D Richardson
Jan 1, 2014·International Scholarly Research Notices·Mohamed Abou-Elwafa Abdallah

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