Analysis of Hypo- and Hyperphosphatemia in an Intensive Care Unit Cohort

Anesthesia and Analgesia
Marcus BromanBengt Klarin

Abstract

Blood phosphate levels are vulnerable to fluctuations and changes in phosphate levels are often neglected. The aim of this study was to evaluate whether deviations in phosphate levels correlate to higher 180-day overall mortality or morbidity. Four thousand six hundred fifty-six patients with 19,467 phosphate values treated at the adult intensive care unit at Skåne University Hospital, Lund, Sweden during 2006-2014 were retrospectively divided into a control group and 3 study groups: hypophosphatemia, hyperphosphatemia, and a mixed group showing both hypo/hyperphosphatemia. Sex, age, disease severity represented by maximal organ system Sequential Organ Failure Assessment score, renal Sequential Organ Failure Assessment score, lowest ionized calcium value, and diagnoses classes were included in a Cox hazard model to adjust for confounding factors, with time to death in the first 180 days from the intensive care unit (ICU) admission as outcome. When compared to normophosphatemic controls, the hyperphosphatemic study group was associated with higher risk of death with a hazard ratio of 1.2 (98.3% confidence interval 1.0-1.5, P = .0089). Mortality in the hypophosphatemic or mixed study group did not differ from controls. The mixed ...Continue Reading

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Citations

Sep 12, 2019·Acta Anaesthesiologica Scandinavica·Gitte Kingo VesterlundAnders Perner
Apr 15, 2020·Calcified Tissue International·Eugénie KoumakisKarine Briot
Aug 14, 2020·Journal of Intensive Care Medicine·Jeremy Cheuk Kin SinAlexis Tabah
Jan 5, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Annika Reintam Blaser, Arthur Raymond Hubert van Zanten
Dec 4, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Annika Reintam BlaserMette M Berger
May 30, 2021·Gastroenterology·Ahmad FarooqRodger A Liddle

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