PMID: 9191885Jul 1, 1997Paper

Analysis of IgG subclasses of human antitopoisomerase I autoantibodies suggests chronic B cell stimulation

Clinical Immunology and Immunopathology
D Vazquez-AbadN Rothfield

Abstract

Antitopoisomerase I autoantibodies are highly specific of scleroderma and are mainly IgG. The present study was designed to evaluate the prevalence of each IgG antitopoisomerase I subclass. An ELISA for the detection of IgG antitopoisomerase I subclasses was standardized and used to study the antibodies from 49 antitopoisomerase I-positive patients identified from a total of 541 patients. Correlations and multivariate analysis were performed to determine the frequency of associations between the IgG antitopoisomerase I subclasses. All IgG antitopoisomerase I subclasses were found. Twelve patients (24.5%) had all four IgG antitopoisomerase I subclasses, 13 (26.5%) had three, 16 (32.7%) had two, and 7 (14.3%) had only one antitopoisomerase I subclass. The presence of all four IgG antitopoisomerase I subclasses suggests that this specific B-cell is the target of multiple activation pathways which indicate that there is a complex T-cell-cytokine-driven process. Together with the absence of other autoantibodies in these sera, our results support the concept of a multiple but highly selected and chronic B-cell activation in scleroderma patients with antitopoisomerase I.

References

Dec 1, 1990·Clinical Immunology and Immunopathology·S HildebrandtN F Rothfield
Mar 1, 1972·Arthritis and Rheumatism·P H SchurN Rothfield
Jan 1, 1995·Clinical Immunology and Immunopathology·W Zhang, M Reichlin
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Sep 1, 1993·The Journal of Clinical Investigation·D Vazquez-AbadN F Rothfield
Jul 1, 1996·Arthritis and Rheumatism·E L MattesonJ J Goronzy

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Citations

Sep 10, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M de MartinoA Vierucci
Sep 10, 1999·Journal of Autoimmunity·H OnouchiY Tomita
May 29, 2015·BMC Musculoskeletal Disorders·Kazuhiro KiyamaTsuneyo Mimori
May 17, 2014·PLoS Pathogens·Eugenia Corrales-AguilarHartmut Hengel
Mar 13, 2014·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Piero PavoneGiovanna Vitaliti
Oct 2, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yukiyoshi FujitaRyuya Horiuchi
Feb 2, 2018·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Katsuji Uno
Apr 14, 2019·British Dental Journal·Oliver ClappRuth M Fairchild
Feb 3, 2005·The Journal of Clinical Endocrinology and Metabolism·Naoki HattoriChiyoko Inagaki
Sep 4, 2020·Biomedicines·Marie-Paule Lefranc, Gérard Lefranc

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