Analysis of IL-6, STAT3 and HSPA1L gene polymorphisms in anti-tuberculosis drug-induced hepatitis in a nested case-control study

PloS One
Jing WangSi-Yan Zhan

Abstract

To investigate the association of IL-6, STAT3 and HSPA1L polymorphisms with the risk of anti-tuberculosis drug-induced hepatitis (ATDH) in Chinese Han population. The study was designed as a nested case-control study within a prospective cohort. Each case was matched with four controls by sex, age at baseline (±5 years), treatment history, disease severity, drug dosage and place of sample collection. Genetic polymorphisms of IL-6, STAT3 and HSPA1L were determined blindly by TaqMan single-nucleotide polymorphism (SNP) genotyping assay. Odds ratio (OR) with 95% confidence intervals (CIs) was estimated by conditional logistic regression model to measure the association between selected SNPs and the risk of ATDH. A total of 89 incident ATDH cases and 356 ATDH-free controls were genotyped for IL-6 (rs2066992, rs2069837, rs1524107), STAT3 (rs1053004, rs1053023, rs1053005) and HSPA1L (rs2227956). In genotype analysis, no significant difference was observed in genotypes frequencies of the seven selected SNPs between case and control group after Bonferroni correction. In haplotype analysis, carriers with STAT3 GAT and AGC (rs1053023-rs1053005-rs1053004) haplotypes had a significantly higher risk of ATDH compared with wild-type haplotype...Continue Reading

References

Dec 16, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C A CamargoP A Clavien
Apr 12, 2000·Journal of Gastroenterology and Hepatology·K Rokutan
May 18, 2000·Journal of Neuroimmunology·J J BajramovićJ M van Noort
Mar 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yi-Shin HuangShou-Dong Lee
May 29, 2002·The Journal of Biological Chemistry·Wei LiRebecca Taub
Nov 20, 2002·The Journal of Clinical Investigation·Feng HongBin Gao
Apr 23, 2003·Biochemical and Biophysical Research Communications·Yasuhiro MasubuchiLance R Pohl
Oct 3, 2003·The Journal of Clinical Investigation·Rebecca Taub
Apr 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rui SunBin Gao
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guruprasad P AithalChristopher P Day
Mar 17, 2005·Cellular and Molecular Life Sciences : CMLS·M P Mayer, B Bukau
Jul 12, 2005·Journal of Leukocyte Biology·Vishal C MehraJeffrey R Bender
Sep 21, 2005·Journal of Clinical Pharmacology·Laura P JamesJack A Hinson
Apr 14, 2006·Handbook of Experimental Pharmacology·C DidelotC Garrido
Oct 6, 2006·American Journal of Respiratory and Critical Care Medicine·Jussi J SaukkonenUNKNOWN ATS (American Thoracic Society) Hepatotoxicity of Antituberculosis Therapy Subcommittee
Jun 22, 2007·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ji-Ye SongMin-Jae Lee
Dec 14, 2007·Pharmacogenetics and Genomics·Daniel F CarrB Kevin Park
May 20, 2008·Journal of Hepatology·Ketevan PachkoriaUNKNOWN Spanish Group for the Study of Drug-Induced Liver Disease (Grupo de Estudio para las Hepatopatías Asociadas a Medicamentos (
Mar 10, 2009·BMC Bioinformatics·Markus TeuberAndre Franke
Jun 2, 2009·Nature Genetics·Ann K DalyUNKNOWN International SAE Consortium
Dec 17, 2009·Cell Stress & Chaperones·Esma Ucisik-AkkayaM Tevfik Dorak
May 10, 2011·International Journal of Biological Sciences·Hua WangBin Gao
Dec 14, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Sang-Heon KimYoung-Koo Jee
Apr 12, 2012·Frontiers in Physiology·Xiaoni KongBin Gao
Apr 18, 2012·Clinical and Experimental Pharmacology & Physiology·Hui-Ru AnYan Liang
Sep 13, 2012·Pharmacogenetics and Genomics·Thomas J UrbanUNKNOWN International Serious Adverse Events Consortium
Nov 13, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Xu LiangJun Ren
Dec 5, 2012·Mutation Research·Mariola Sliwinska-Kowalska, Malgorzata Pawelczyk
Feb 12, 2013·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·N P C SantosM H Hutz
Feb 22, 2013·Journal of Gastroenterology and Hepatology·Jun ChenJieshou Li
Aug 22, 2014·TheScientificWorldJournal·Lei HeHe-sheng Luo

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Citations

Feb 2, 2016·European Journal of Internal Medicine·Anna Licata
Jun 26, 2018·British Journal of Biomedical Science·S M MirnooriH S Saedi

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Methods Mentioned

BETA
X-ray
genotyping
PCR

Software Mentioned

Haploview
Quanto
SPSS
PHASE

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