Analysis of immunoglobulin G subclass in the serum antibody responses of alveolar echinococcosis patients after surgical treatment and chemotherapy as an aid to assessing the outcome

Transactions of the Royal Society of Tropical Medicine and Hygiene
H WenP S Craig

Abstract

Immunoglobulin G (IgG) subclass-specific antibody responses were evaluated for the follow-up of alveolar echinococcosis (AE) patients. Seventy-four sequentially collected sera from 25 Chinese and French AE cases who underwent surgery including hepatectomy, liver transplant and/or chemotherapy were analysed quantitatively and qualitatively during the clinical follow-up period. These AE patients were classified in 4 groups--cured, improved, stabilized, or aggravated. Serum antibody levels of the subclasses IgG1 and IgG4 were significantly higher in the AE patients than in healthy controls. IgG1 and IgG4 isotypes in AE patients were the most sensitive IgG antibody response in an enzyme-linked immunosorbent assay (ELISA) and in binding to antigens of 44kDa, 35kDa, 21kDa and 17.5kDa in an Echinococcus multilocularis protoscolex extract after Western blotting. In AE cases classed as cured or improved, IgG subclass antibody levels tended to decrease earlier than total IgG levels, especially IgG4 antibody levels which became negative within one year after successful treatment. IgG4 antibody levels also decreased in most of the improved cases. Increasing or unchanged levels of IgG4 and IgG1 antibodies were demonstrated in both stabilize...Continue Reading

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Citations

May 18, 2004·Clinical Reviews in Allergy & Immunology·Dominique A Vuitton
Apr 18, 2012·World Journal of Gastroenterology : WJG·Giuseppe NunnariBruno Cacopardo
Mar 27, 2010·Journal of Biomedicine & Biotechnology·Dominique Angèle Vuitton, Bruno Gottstein
Apr 14, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D CarmenaE Eraso
Nov 17, 2011·PLoS Neglected Tropical Diseases·Victoria Martínez-SernándezFlorencio M Ubeira
Oct 13, 2016·World Journal of Hepatology·Memmet MihmanliEmre Bozkurt
Feb 15, 2019·Frontiers in Public Health·Monika WetscherGeorg G Duscher

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