Analysis of incidence of infection with enterotoxigenic Escherichia coli in a prospective cohort study of infant diarrhea in Nicaragua.

Journal of Clinical Microbiology
M PaniaguaH Hallander

Abstract

Diarrheal episodes with enterotoxigenic Escherichia coli (ETEC) were prospectively monitored during the first 2 years of life in a cohort of 235 infants from Leon, Nicaragua. ETEC was an etiological finding in 38% (310 of 808) of diarrheal episodes and in 19% (277 of 1,472) of samples taken as asymptomatic controls at defined age intervals (P = <0.0001). The majority of diarrheal episodes (80%) occurred before 12 months of age. The major ETEC type was characterized by colonization factor CFA I and elaboration of both heat-labile enterotoxin and heat-stable enterotoxin (ST). The proportion of E. coli strains with CFA I was significantly higher in cases with diarrhea (P = 0.002). The second most prevalent type showed putative colonization factor PCFO166 and production of ST. The prevalence of PCFO166 was approximately 20%, higher than reported before. Children with a first CFA I episode contracted a second ETEC CFA I infection 24% of the time, compared with 46% for ETEC strains of any subtype. Most of the ETEC episodes were of moderate severity, and only 5% (15 of 310) were characterized as severe. In conclusion, our results give valuable information for the planning of intervention studies using ETEC vaccines.

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Citations

Sep 15, 2001·FEMS Microbiology Letters·I R de OliveiraL G Giugliano
Aug 15, 2009·Journal of Medical Microbiology·Daniel ReyesInger Kühn
Oct 23, 2010·Journal of Medical Microbiology·Erick AmayaAndrej Weintraub
Mar 30, 2010·Journal of Bacteriology·Karina Mazariego-EspinosaJuan Xicohtencatl-Cortes
Jun 1, 2014·The Pediatric Infectious Disease Journal·Sylvia Becker-DrepsMargarita Paniagua
Feb 28, 2004·FEMS Immunology and Medical Microbiology·Adriana Hamond Regua-MangiaLúcia Martins Teixeira
Apr 17, 2009·Journal of Medical Microbiology·Samuel VilchezAndrej Weintraub
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Aug 17, 1999·Journal of Clinical Microbiology·G I ViboudA M Svennerholm
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