PMID: 2501395Jul 1, 1989Paper

Analysis of initial melanogenesis including tyrosinase transfer and melanosome differentiation through interrupted melanization by glutathione

The Journal of Investigative Dermatology
G Imokawa

Abstract

Because glycosylation-dependent melanization inhibition induced in cultured B-16 melanoma cells by glucosamine is reversible, producing synchronized initiation of melanogenesis after its removal, we have analyzed the possible dynamics of initial melanogenesis through their interruption by glutathione. The addition of glutathione at 0.2% concentration to the theophylline-stimulated recovery process completely interrupts the initiation of melanization for at least 72 h. At the electron microscopic level, theophylline-treated cells have many vacuolar melanosomes with distinct pigmentation which contain some vesicles (64% of total premelanosomes) or amorphous, filamentous, or granular materials within the interior which are suggestive of pheomelanotic melanosomes. The addition of glutathione induces a complete absence of melanization in the premelanosomes, within which a filamentous interior with periodicity is generally re-formed with almost complete disappearance of internal vesicles, providing dramatic changes to the size and shape characteristic of eumelanotic melanosome. Electron microscopic dopa reaction of glutathione-treated cells shows a predominant localization of tyrosinase activity in the Golgi-associated endoplasmic re...Continue Reading

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Citations

Jun 15, 2011·Bioscience, Biotechnology, and Biochemistry·Huey-Chun HuangTsong-Min Chang
Jul 19, 2012·World Journal of Microbiology & Biotechnology·Huey-Chun Huang, Tsong-Min Chang
Dec 1, 2007·Journal of Cosmetic Dermatology·Donald L BissettMichael K Robinson
Nov 6, 2007·Biological & Pharmaceutical Bulletin·Takako Yokozawa, You Jung Kim
Jun 8, 2012·BMC Complementary and Alternative Medicine·Huey-Chun HuangTsong-Min Chang
May 22, 2008·International Journal of Cosmetic Science·C D Villarama, H I Maibach
Mar 14, 2007·Journal of Cosmetic Dermatology·Donald L BissettGary R Kelm
Nov 11, 2011·International Journal of Molecular Sciences·Yang YaoGuixing Ren
Jul 3, 2009·Biological & Pharmaceutical Bulletin·You Jung Kim, Takako Yokozawa
Oct 30, 2009·International Journal of Molecular Sciences·Jody P EbanksRaymond E Boissy
Mar 31, 2015·International Journal of Cosmetic Science·C-H YangW-L Chen
Jun 29, 2014·BMC Complementary and Alternative Medicine·Huey-Chun HuangTsong-Min Chang
Jul 27, 1999·The British Journal of Dermatology·Y FunasakaM Ichihashi
Jun 2, 2007·Biological & Pharmaceutical Bulletin·You-Jung Kim
Jul 4, 2012·International Journal of Molecular Sciences·Huey-Chun HuangTsong-Min Chang
Jan 6, 2006·Biological & Pharmaceutical Bulletin·Jae Kyung NoHae Young Chung
Dec 5, 2014·Expert Review of Clinical Pharmacology·Kabir Sardana, Sneha Ghunawat
Jul 28, 2019·Bioorganic & Medicinal Chemistry·Sanggwon LeeHyung Ryong Moon
Jan 5, 2000·The Journal of Investigative Dermatology·L QiuP G Parsons
Jan 16, 2007·The Journal of Investigative Dermatology·Hideya AndoVincent J Hearing

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