Analysis of interleukin-10 gene polymorphisms in patients with chronic periodontitis and healthy controls

Dental Research Journal
Bita MoudiMehrnoosh Moudi

Abstract

Interleukin-10 (IL-10) is an anti-inflammatory cytokine that has important roles in the periodontal diseases. The IL10-1082, -819, and -592 polymorphisms in the promoter region of IL-10 gene have been associated with various IL-10 expressions. The aim of this study was to investigate the association between these gene polymorphisms with chronic periodontitis in a sample of Iranian populations from Southeast of Iran. IL-10 single nucleotide polymorphisms were analyzed in 210 patients with chronic periodontitis (CP) and 100 individuals without CP by polymerase chain reaction-restriction fragment length polymorphism method. Statistical analysis of data was performed using the Chi-square test. The risk associated with single alleles, genotypes, and haplotypes were calculated by performing a multiple logistic regression analysis to estimate the odds ratio (OR) and 95% confidence interval (CI). P < 0.05 for statistical significance. The prevalences of AG and GG genotypes of IL10-1082 were significantly different between CP and control groups in comparison to AA genotype (OR = 2.671; CI = 1.482-4.815; P = 0.001 for AG vs. AA, OR = 4.151; CI = 2.128-8.097; P < 0.001 for GG vs. AA). In addition, subjects with at least one IL10-1082-G al...Continue Reading

Citations

Nov 7, 2019·Indian Journal of Clinical Biochemistry : IJCB·Bita MoudiHamidreza Mahmoudzadeh-Sagheb
May 6, 2019·Oral Diseases·Mohaddeseh EmampanahiElham Fakhari
Nov 17, 2021·European Journal of Dentistry·Chaerita MaulaniNurtami Soedarsono

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Methods Mentioned

BETA
genotyping
electrophoresis
biopsies

Software Mentioned

SPSS

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